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Magt1 magnesium transporter 1 [ Mus musculus (house mouse) ]

Gene ID: 67075, updated on 5-Mar-2024

Summary

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Official Symbol
Magt1provided by MGI
Official Full Name
magnesium transporter 1provided by MGI
Primary source
MGI:MGI:1914325
See related
Ensembl:ENSMUSG00000031232 AllianceGenome:MGI:1914325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IAP; IAG2; 2410001C15Rik; 2610529C04Rik; 2810482I07Rik
Summary
Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Used to study primary immunodeficiency disease. Human ortholog(s) of this gene implicated in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia; congenital disorder of glycosylation Icc; and non-syndromic X-linked intellectual disability. Orthologous to human MAGT1 (magnesium transporter 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 16.4), limb E14.5 (RPKM 8.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Magt1 in Genome Data Viewer
Location:
X D; X 47.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105011690..105055408, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (105968084..106011802, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ATRX, chromatin remodeler Neighboring gene ribosomal protein 17a pseudogene Neighboring gene predicted gene, 23656 Neighboring gene STARR-seq mESC enhancer starr_47729 Neighboring gene STARR-seq mESC enhancer starr_47730 Neighboring gene STARR-positive B cell enhancer ABC_E5734 Neighboring gene cytochrome c oxidase subunit 7B Neighboring gene ATPase, Cu++ transporting, alpha polypeptide Neighboring gene STARR-seq mESC enhancer starr_47732 Neighboring gene STARR-seq mESC enhancer starr_47734

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice. Gotru SK, et al. J Immunol, 2018 Apr 15. PMID 29581357
  2. Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties. Goytain A, et al. BMC Genomics, 2005 Apr 1. PMID 15804357, Free PMC Article
  3. Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters. Zocchi M, et al. Int J Mol Sci, 2022 Jan 31. PMID 35163580, Free PMC Article
  4. Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Ramírez AS, et al. Science, 2019 Dec 13. PMID 31831667
  5. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
    Title: MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
  2. Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
    Title: Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
  3. identifed a novel gene that encodes a protein involved with Mg2+-evoked transport, MagT1; results suggest that MagT1 may provide a selective and regulated pathway for Mg2+ transport in epithelial cells[MagT1]
    Title: Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
magnesium transporter protein 1
Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1
implantation-associated protein
oligosaccharyl transferase subunit MAGT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190409.2 → NP_001177338.2  magnesium transporter protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL670660, AL672288
    Consensus CDS
    CCDS53168.2
    UniProtKB/Swiss-Prot
    Q3UW45, Q9CQY5, Q9CWX5, Q9CZT3
    UniProtKB/TrEMBL
    A2ADH1
    Related
    ENSMUSP00000120994.3, ENSMUST00000151689.9
    Conserved Domains (1) summary
    pfam04756
    Location:42 → 330
    OST3_OST6; OST3 / OST6 family, transporter family

  2. NM_001377002.1 → NP_001363931.1  magnesium transporter protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL670660, AL672288
    UniProtKB/TrEMBL
    A2ADH1
    Conserved Domains (1) summary
    pfam04756
    Location:42 → 338
    OST3_OST6; OST3 / OST6 family, transporter family

  3. NM_001377003.1 → NP_001363932.1  magnesium transporter protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL670660, AL672288
    UniProtKB/TrEMBL
    A2ADH1
    Conserved Domains (1) summary
    pfam04756
    Location:42 → 329
    OST3_OST6; OST3 / OST6 family, transporter family

  4. NM_025952.5 → NP_080228.5  magnesium transporter protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL670660, AL672288
    Consensus CDS
    CCDS53168.2
    UniProtKB/Swiss-Prot
    Q3UW45, Q9CQY5, Q9CWX5, Q9CZT3
    UniProtKB/TrEMBL
    A2ADH1
    Related
    ENSMUSP00000033583.8, ENSMUST00000033583.14
    Conserved Domains (1) summary
    pfam04756
    Location:42 → 330
    OST3_OST6; OST3 / OST6 family, transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    105011690..105055408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQY5.1 GenPept UniProtKB/Swiss-Prot:Q9CQY5

Gene LinkOut

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