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Pi4k2b phosphatidylinositol 4-kinase type 2 beta [ Mus musculus (house mouse) ]

Gene ID: 67073, updated on 11-Apr-2024

Summary

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Official Symbol
Pi4k2bprovided by MGI
Official Full Name
phosphatidylinositol 4-kinase type 2 betaprovided by MGI
Primary source
MGI:MGI:1914323
See related
Ensembl:ENSMUSG00000029186 AllianceGenome:MGI:1914323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610042N09Rik; 4933409G22Rik
Summary
Predicted to enable 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in Golgi organization; endosome organization; and phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm and membrane. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Orthologous to human PI4K2B (phosphatidylinositol 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 17.6), duodenum adult (RPKM 15.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C1; 5 28.63 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52898903..52926686)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52741561..52769344)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30178 Neighboring gene STARR-seq mESC enhancer starr_13066 Neighboring gene Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase Neighboring gene STARR-seq mESC enhancer starr_13067 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:53060867-53061054 Neighboring gene STARR-seq mESC enhancer starr_13069 Neighboring gene zinc finger, CCHC domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E3575 Neighboring gene anaphase promoting complex subunit 4 Neighboring gene STARR-seq mESC enhancer starr_13070

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. Jones DR, et al. Mol Cell, 2006 Sep 1. PMID 16949365
  2. NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway. Mora S, et al. J Biol Chem, 2002 Jul 26. PMID 12011096
  3. Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated beta-cells. Wuttke A, et al. J Cell Sci, 2010 May 1. PMID 20375060
  4. Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. Balla A, et al. J Biol Chem, 2002 May 31. PMID 11923287
  5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PI 4-kinase functions to negatively regulate GLUT4 translocation through its interaction with NCS-1.
    Title: NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway.
  2. UV irradiation increases nuclear PtdIns5P levels via inhibition of the activity of the beta isoform of PtdIns5P 4-kinase (PIP4Kbeta), an enzyme that can phosphorylate and remove PtdIns5P.
    Title: Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol 4-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-kinase type 2-beta
Names
phosphatidylinositol 4-kinase type II-beta
NP_080227.2
NP_083020.2
XP_006504127.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025951.3 → NP_080227.2  phosphatidylinositol 4-kinase type 2-beta isoform 1

    See identical proteins and their annotated locations for NP_080227.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK011751, AK035523, BY140598
    Consensus CDS
    CCDS19287.1
    UniProtKB/Swiss-Prot
    Q8CBQ5, Q91Z30, Q9D072, Q9D471
    Related
    ENSMUSP00000031081.5, ENSMUST00000031081.11
    Conserved Domains (1) summary
    pfam00454
    Location:118 → 415
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

  2. NM_028744.3 → NP_083020.2  phosphatidylinositol 4-kinase type 2-beta isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon and lacks a different alternate exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK011751, AK016754, AK035523, BY140598
    Consensus CDS
    CCDS39086.1
    UniProtKB/Swiss-Prot
    Q8CBQ5
    Related
    ENSMUSP00000031082.7, ENSMUST00000031082.8
    Conserved Domains (1) summary
    pfam00454
    Location:108 → 392
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    52898903..52926686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504064.2 → XP_006504127.1  phosphatidylinositol 4-kinase type 2-beta isoform X1

    Conserved Domains (1) summary
    pfam00454
    Location:36 → 322
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CBQ5.1 GenPept UniProtKB/Swiss-Prot:Q8CBQ5

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