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Cdc37l1 cell division cycle 37-like 1 [ Mus musculus (house mouse) ]

Gene ID: 67072, updated on 5-Mar-2024

Summary

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Official Symbol
Cdc37l1provided by MGI
Official Full Name
cell division cycle 37-like 1provided by MGI
Primary source
MGI:MGI:1914322
See related
Ensembl:ENSMUSG00000024780 AllianceGenome:MGI:1914322
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Harc; Cdc37l; 2700033A15Rik
Summary
This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in cerebellum adult (RPKM 8.6), cortex adult (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C1; 19 23.61 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (28959049..29008832)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (28990337..29026664)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA hydroxylase pseudogene Neighboring gene tektin 5 like Neighboring gene adenylate kinase 3 Neighboring gene STARR-seq mESC enhancer starr_45875 Neighboring gene ribosomal protein L26 pseudogene Neighboring gene RIKEN cDNA 1700018L02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1523 Neighboring gene STARR-seq mESC enhancer starr_45878 Neighboring gene predicted gene 9895

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock. Cartledge K, et al. Biochemistry, 2007 Dec 25. PMID 18052042
  2. Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37. Scholz GM, et al. J Biol Chem, 2001 Aug 17. PMID 11413142
  3. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hsp90 co-chaperone Cdc37-like 1
Names
Hsp90-associating relative of Cdc37
cell division cycle 37 homolog-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302380.2 → NP_001289309.1  hsp90 co-chaperone Cdc37-like 1 isoform 2

    See identical proteins and their annotated locations for NP_001289309.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113961
    Consensus CDS
    CCDS89372.1
    UniProtKB/TrEMBL
    A0A286YCB4
    Related
    ENSMUSP00000152985.2, ENSMUST00000224511.2
    Conserved Domains (2) summary
    smart01070
    Location:138 → 280
    CDC37_M; Cdc37 Hsp90 binding domain
    cl03951
    Location:71 → 139
    CDC37_N; Cdc37 N terminal kinase binding

  2. NM_001302382.2 → NP_001289311.1  hsp90 co-chaperone Cdc37-like 1 isoform 3

    See identical proteins and their annotated locations for NP_001289311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113961
    Consensus CDS
    CCDS89371.1
    UniProtKB/TrEMBL
    A0A286YCB4
    Related
    ENSMUSP00000153192.2, ENSMUST00000225310.2
    Conserved Domains (2) summary
    smart01070
    Location:138 → 280
    CDC37_M; Cdc37 Hsp90 binding domain
    cl03951
    Location:71 → 139
    CDC37_N; Cdc37 N terminal kinase binding

  3. NM_001302443.2 → NP_001289372.1  hsp90 co-chaperone Cdc37-like 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113961
    UniProtKB/Swiss-Prot
    Q9CZP7
    Conserved Domains (2) summary
    smart01070
    Location:138 → 280
    CDC37_M; Cdc37 Hsp90 binding domain
    cl03951
    Location:71 → 139
    CDC37_N; Cdc37 N terminal kinase binding

  4. NM_001377047.1 → NP_001363976.1  hsp90 co-chaperone Cdc37-like 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC113961
    Conserved Domains (2) summary
    smart01070
    Location:138 → 280
    CDC37_M; Cdc37 Hsp90 binding domain
    cl03951
    Location:71 → 139
    CDC37_N; Cdc37 N terminal kinase binding

  5. NM_025950.4 → NP_080226.1  hsp90 co-chaperone Cdc37-like 1 isoform 1

    See identical proteins and their annotated locations for NP_080226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC113961
    Consensus CDS
    CCDS29729.1
    UniProtKB/Swiss-Prot
    Q3TNC7, Q8BP15, Q8C892, Q8C8X2, Q9CU15, Q9CZP7
    Related
    ENSMUSP00000060421.4, ENSMUST00000050148.5
    Conserved Domains (2) summary
    smart01070
    Location:138 → 280
    CDC37_M; Cdc37 Hsp90 binding domain
    cl03951
    Location:71 → 139
    CDC37_N; Cdc37 N terminal kinase binding

RNA

  1. NR_165053.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC113961

  2. NR_165054.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC113961

  3. NR_165055.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC113961

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    28959049..29008832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004940168.1 RNA Sequence

  2. XR_003952810.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZP7.1 GenPept UniProtKB/Swiss-Prot:Q9CZP7

Gene LinkOut

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