U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lsm14a LSM14A mRNA processing body assembly factor [ Mus musculus (house mouse) ]

Gene ID: 67070, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Lsm14aprovided by MGI
Official Full Name
LSM14A mRNA processing body assembly factorprovided by MGI
Primary source
MGI:MGI:1914320
See related
Ensembl:ENSMUSG00000066568 AllianceGenome:MGI:1914320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tral; mRAP55A; 2700023B17Rik
Summary
Enables double-stranded DNA binding activity; double-stranded RNA binding activity; and single-stranded RNA binding activity. Acts upstream of or within RIG-I signaling pathway and positive regulation of type I interferon-mediated signaling pathway. Located in P-body. Is expressed in several structures, including gonad. Orthologous to human LSM14A (LSM14A mRNA processing body assembly factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 24.1), limb E14.5 (RPKM 17.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 B1; 7 19.56 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (34043569..34089134, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34344144..34390026, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18586 Neighboring gene predicted gene 12762 Neighboring gene predicted gene 12758 Neighboring gene granule associated Rac and RHOG effector 1 Neighboring gene VISTA enhancer mm1379 Neighboring gene STARR-seq mESC enhancer starr_18591 Neighboring gene 39S ribosomal protein L27, mitochondrial pseudogene Neighboring gene predicted gene 12764 Neighboring gene predicted gene, 35297 Neighboring gene predicted gene 12784

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mouse oocytes within germ cell cysts and primordial follicles contain a Balbiani body. Pepling ME, et al. Proc Natl Acad Sci U S A, 2007 Jan 2. PMID 17189423, Free PMC Article
  2. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Li Y, et al. Proc Natl Acad Sci U S A, 2012 Jul 17. PMID 22745163, Free PMC Article
  3. Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. van Dijk TB, et al. Mol Cell Biol, 2010 Jan. PMID 19858291, Free PMC Article
  4. LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner. Liu TT, et al. J Immunol, 2016 Jun 15. PMID 27183626
  5. Variegated gene expression caused by cell-specific long-range DNA interactions. Noordermeer D, et al. Nat Cell Biol, 2011 Jun 26. PMID 21706023, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that LSm14A plays an important role in antiviral innate and adaptive immune responses by modulating MITA level in a cell type-specific manner
    Title: LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in P-body assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in P-body assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within RIG-I signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein LSM14 homolog A
Names
LSM14 homolog A
RNA-associated protein 55A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360654.1 → NP_001347583.1  protein LSM14 homolog A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' end compared to variant 1. The resulting isoform (2) is the same length but has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BX537302, BX539342
    Conserved Domains (2) summary
    cd01736
    Location:4 → 77
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:290 → 398
    FDF; FDF domain

  2. NM_001360655.1 → NP_001347584.1  protein LSM14 homolog A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    BX537302, BX539342
    Conserved Domains (2) summary
    cd01736
    Location:4 → 77
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:290 → 397
    FDF; FDF domain

  3. NM_001360656.1 → NP_001347585.1  protein LSM14 homolog A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BX537302, BX539342
    Conserved Domains (2) summary
    cd01736
    Location:4 → 77
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:231 → 339
    FDF; FDF domain

  4. NM_025948.3 → NP_080224.1  protein LSM14 homolog A isoform 1

    See identical proteins and their annotated locations for NP_080224.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BX537302, BX539342
    Consensus CDS
    CCDS21140.1
    UniProtKB/Swiss-Prot
    Q8K2F8, Q9CTG8
    Related
    ENSMUSP00000082723.6, ENSMUST00000085585.12
    Conserved Domains (2) summary
    cd01736
    Location:4 → 77
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:290 → 398
    FDF; FDF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    34043569..34089134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242918.2 → XP_030098778.1  protein LSM14 homolog A isoform X1

    Conserved Domains (2) summary
    cd01736
    Location:4 → 77
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:290 → 397
    FDF; FDF domain

  2. XM_017312254.3 → XP_017167743.1  protein LSM14 homolog A isoform X3

    Conserved Domains (2) summary
    cd01736
    Location:4 → 77
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:231 → 339
    FDF; FDF domain

  3. XM_036153375.1 → XP_036009268.1  protein LSM14 homolog A isoform X4

    Conserved Domains (2) summary
    cd01736
    Location:4 → 77
    LSm14_N; Like-Sm protein 14, N-terminal domain
    pfam09532
    Location:231 → 338
    FDF; FDF domain

  4. XM_011250679.4 → XP_011248981.1  protein LSM14 homolog A isoform X2

    Conserved Domains (2) summary
    pfam09532
    Location:254 → 362
    FDF; FDF domain
    cl00259
    Location:4 → 41
    Sm_like; Sm and related proteins

  5. XM_011250681.4 → XP_011248983.1  protein LSM14 homolog A isoform X5

    Conserved Domains (2) summary
    pfam09532
    Location:195 → 303
    FDF; FDF domain
    cl00259
    Location:4 → 41
    Sm_like; Sm and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2F8.1 GenPept UniProtKB/Swiss-Prot:Q8K2F8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous