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Dynlrb1 dynein light chain roadblock-type 1 [ Mus musculus (house mouse) ]

Gene ID: 67068, updated on 21-Apr-2024

Summary

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Official Symbol
Dynlrb1provided by MGI
Official Full Name
dynein light chain roadblock-type 1provided by MGI
Primary source
MGI:MGI:1914318
See related
Ensembl:ENSMUSG00000047459 AllianceGenome:MGI:1914318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DNLC2A; Dncl2a; km23-1; 2010012N15Rik; 2010320M17Rik; 9430076K19Rik
Summary
Enables identical protein binding activity. Predicted to be involved in microtubule-based movement and visual behavior. Part of cytoplasmic dynein complex. Is expressed in central nervous system; dorsal root ganglion; and retina. Orthologous to human DYNLRB1 (dynein light chain roadblock-type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 150.1), whole brain E14.5 (RPKM 121.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 77.07 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155078453..155092197)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155236533..155250277)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene itchy, E3 ubiquitin protein ligase Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene predicted gene, 52565 Neighboring gene microtubule-associated protein 1 light chain 3 alpha Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene microRNA 695

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cautionary tail: the presence of an N-terminal tag on dynein light-chain Roadblock/LC7 affects its interaction with a functional partner. Song J, et al. Protein Pept Lett, 2007. PMID 17346231
  2. N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance. Ripon MKH, et al. Cell Death Dis, 2020 Aug 14. PMID 32796833, Free PMC Article
  3. Role of km23-1 in RhoA/actin-based cell migration. Jin Q, et al. Biochem Biophys Res Commun, 2012 Nov 23. PMID 23079622, Free PMC Article
  4. The Roadblock light chains are ubiquitous components of cytoplasmic dynein that form homo- and heterodimers. Nikulina K, et al. Cell Motil Cytoskeleton, 2004 Apr. PMID 14752807
  5. DYNLRB1 is essential for dynein mediated transport and neuronal survival. Terenzio M, et al. Neurobiol Dis, 2020 Jul. PMID 32088381, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.
    Title: Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.
  2. N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance.
    Title: N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance.
  3. The presence of an N-terminal tag on dynein light-chain Roadblock/LC7 affects its interaction with a functional partner.
    Title: Cautionary tail: the presence of an N-terminal tag on dynein light-chain Roadblock/LC7 affects its interaction with a functional partner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC159313, MGC159351

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein light chain roadblock-type 1
Names
dynein light chain 2A, cytoplasmic
dynein, cytoplasmic, light chain 2A
dynein, cytoplasmic, light polypeptide 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291108.1 → NP_001278037.1  dynein light chain roadblock-type 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    CJ136086, CO041603
    Consensus CDS
    CCDS71166.1
    UniProtKB/TrEMBL
    A2AVR9
    Related
    ENSMUSP00000114928.2, ENSMUST00000150602.2
    Conserved Domains (1) summary
    smart00960
    Location:12 → 99
    Robl_LC7; Roadblock/LC7 domain

  2. NM_025947.3 → NP_080223.2  dynein light chain roadblock-type 1 isoform b

    See identical proteins and their annotated locations for NP_080223.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK166685, AL929588, CO041603
    Consensus CDS
    CCDS38294.1
    UniProtKB/Swiss-Prot
    A2AVR8, O88567, P62627, Q4FZJ8, Q9D812
    Related
    ENSMUSP00000105304.3, ENSMUST00000109682.9
    Conserved Domains (1) summary
    smart00960
    Location:4 → 91
    Robl_LC7; Roadblock/LC7 domain

RNA

  1. NR_111890.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in its 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL929588, CJ136086, CO041603

  2. NR_111891.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK002359, AL929588, CO041603
    Related
    ENSMUST00000054912.15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155078453..155092197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62627.3 GenPept UniProtKB/Swiss-Prot:P62627

Gene LinkOut

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