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Pgap4 post-GPI attachment to proteins GalNAc transferase 4 [ Mus musculus (house mouse) ]

Gene ID: 67063, updated on 5-Mar-2024

Summary

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Official Symbol
Pgap4provided by MGI
Official Full Name
post-GPI attachment to proteins GalNAc transferase 4provided by MGI
Primary source
MGI:MGI:1914313
See related
Ensembl:ENSMUSG00000039611 AllianceGenome:MGI:1914313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem246; 2810432L12Rik; 9330170P15Rik
Summary
Predicted to enable glycosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in ganglia; nucleus pulposus; and thymus primordium. Orthologous to human PGAP4 (post-GPI attachment to proteins GalNAc transferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in stomach adult (RPKM 29.0), colon adult (RPKM 23.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 26.63 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49584506..49597876, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49584506..49597876, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 189 Neighboring gene aldolase B, fructose-bisphosphate Neighboring gene predicted gene, 33106 Neighboring gene predicted gene, 33159 Neighboring gene STARR-seq mESC enhancer starr_10187 Neighboring gene STARR-positive B cell enhancer ABC_E2112 Neighboring gene predicted gene, 45952

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology. Hirata T, et al. J Biol Chem, 2022 Mar. PMID 35151686, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
post-GPI attachment to proteins factor 4
Names
transmembrane protein 246
transmembrane protein C9orf125 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355503.1 → NP_001342432.1  post-GPI attachment to proteins factor 4

    Status: VALIDATED

    Source sequence(s)
    AK042679, AK045523, AL772310, CK626914, CX238824
    Consensus CDS
    CCDS18177.1
    UniProtKB/Swiss-Prot
    Q3TN50, Q91YV9, Q9CYX3
    Conserved Domains (1) summary
    cd22190
    Location:25 → 395
    PGAP4; Post-GPI attachment to proteins factor 4

  2. NM_025944.4 → NP_080220.2  post-GPI attachment to proteins factor 4

    See identical proteins and their annotated locations for NP_080220.2

    Status: VALIDATED

    Source sequence(s)
    AK042679, AK045523
    Consensus CDS
    CCDS18177.1
    UniProtKB/Swiss-Prot
    Q3TN50, Q91YV9, Q9CYX3
    Related
    ENSMUSP00000040885.3, ENSMUST00000042750.3
    Conserved Domains (1) summary
    cd22190
    Location:25 → 395
    PGAP4; Post-GPI attachment to proteins factor 4

RNA

  1. NR_149725.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK042679, AK045523, AL772310, CK626914, CX238824

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    49584506..49597876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538195.4 → XP_006538258.1  post-GPI attachment to proteins factor 4 isoform X1

    See identical proteins and their annotated locations for XP_006538258.1

    UniProtKB/Swiss-Prot
    Q3TN50, Q91YV9, Q9CYX3
    Conserved Domains (1) summary
    cd22190
    Location:25 → 395
    PGAP4; Post-GPI attachment to proteins factor 4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YV9.1 GenPept UniProtKB/Swiss-Prot:Q91YV9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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