U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rbm25 RNA binding motif protein 25 [ Mus musculus (house mouse) ]

Gene ID: 67039, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Rbm25provided by MGI
Official Full Name
RNA binding motif protein 25provided by MGI
Primary source
MGI:MGI:1914289
See related
Ensembl:ENSMUSG00000010608 AllianceGenome:MGI:1914289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RNPC7; 2600011C06Rik; 2610015J01Rik; A130095G20Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Predicted to act upstream of or within RNA splicing; apoptotic process; and mRNA processing. Predicted to be located in nuclear speck. Is expressed in central nervous system and sensory organ. Orthologous to human RBM25 (RNA binding motif protein 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 31.0), CNS E14 (RPKM 19.1) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12 D1; 12 38.81 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (83678990..83729901)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83632208..83683127)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9860 Neighboring gene STARR-seq mESC enhancer starr_32707 Neighboring gene STARR-seq mESC enhancer starr_32708 Neighboring gene DDB1 and CUL4 associated factor 4 Neighboring gene zinc finger, FYVE domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_32712 Neighboring gene STARR-positive B cell enhancer ABC_E1444 Neighboring gene STARR-seq mESC enhancer starr_32714 Neighboring gene STARR-seq mESC enhancer starr_32715 Neighboring gene H2A histone family, member Z pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7159 Neighboring gene presenilin 1 Neighboring gene STARR-positive B cell enhancer ABC_E3061 Neighboring gene farnesyl diphosphate synthetase pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice. Bramlett C, et al. Blood, 2023 Jun 15. PMID 36947858,
  2. The splicing factor RBM25 controls MYC activity in acute myeloid leukemia. Ge Y, et al. Nat Commun, 2019 Jan 11. PMID 30635567, Free PMC Article
  3. Analysis of phosphorylation-dependent protein-protein interactions of histone h3. Klingberg R, et al. ACS Chem Biol, 2015 Jan 16. PMID 25330109
  4. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
  5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice.
    Title: RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice.
  2. tumor suppressive function in acute myeloid leukemia
    Title: The splicing factor RBM25 controls MYC activity in acute myeloid leukemia.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
RNA-binding protein 25

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364415.1 → NP_001351344.1  RNA-binding protein 25 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC055772
    Conserved Domains (2) summary
    smart00311
    Location:777 → 850
    PWI; domain in splicing factors
    cd12446
    Location:106 → 188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  2. NM_001364416.1 → NP_001351345.1  RNA-binding protein 25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC055772
    Consensus CDS
    CCDS49107.1
    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Conserved Domains (2) summary
    smart00311
    Location:758 → 831
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  3. NM_027349.4 → NP_081625.3  RNA-binding protein 25 isoform 2

    See identical proteins and their annotated locations for NP_081625.3

    Status: VALIDATED

    Source sequence(s)
    AC055772, AK011403, AK142132, BY169048, CJ063347
    Consensus CDS
    CCDS49107.1
    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Related
    ENSMUSP00000048470.9, ENSMUST00000048155.16
    Conserved Domains (2) summary
    smart00311
    Location:758 → 831
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    83678990..83729901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157593.1 → XP_036013486.1  RNA-binding protein 25 isoform X4

    Conserved Domains (2) summary
    smart00311
    Location:740 → 813
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  2. XM_006516166.4 → XP_006516229.1  RNA-binding protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006516229.1

    Conserved Domains (2) summary
    smart00311
    Location:777 → 850
    PWI; domain in splicing factors
    cd12446
    Location:106 → 188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  3. XM_036157590.1 → XP_036013483.1  RNA-binding protein 25 isoform X2

    Conserved Domains (2) summary
    smart00311
    Location:759 → 832
    PWI; domain in splicing factors
    cd12446
    Location:106 → 188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  4. XM_006516168.5 → XP_006516231.1  RNA-binding protein 25 isoform X3

    See identical proteins and their annotated locations for XP_006516231.1

    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Conserved Domains (2) summary
    smart00311
    Location:758 → 831
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  5. XM_006516164.5 → XP_006516227.1  RNA-binding protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006516227.1

    Conserved Domains (2) summary
    smart00311
    Location:777 → 850
    PWI; domain in splicing factors
    cd12446
    Location:106 → 188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  6. XM_036157594.1 → XP_036013487.1  RNA-binding protein 25 isoform X4

    Conserved Domains (2) summary
    smart00311
    Location:740 → 813
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  7. XM_036157595.1 → XP_036013488.1  RNA-binding protein 25 isoform X4

    Conserved Domains (2) summary
    smart00311
    Location:740 → 813
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  8. XM_030246879.2 → XP_030102739.1  RNA-binding protein 25 isoform X5

    Conserved Domains (1) summary
    smart00311
    Location:554 → 627
    PWI; domain in splicing factors

  9. XM_036157591.1 → XP_036013484.1  RNA-binding protein 25 isoform X3

    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Conserved Domains (2) summary
    smart00311
    Location:758 → 831
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  10. XM_036157596.1 → XP_036013489.1  RNA-binding protein 25 isoform X5

    Conserved Domains (1) summary
    smart00311
    Location:554 → 627
    PWI; domain in splicing factors

  11. XM_006516165.5 → XP_006516228.1  RNA-binding protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006516228.1

    Conserved Domains (2) summary
    smart00311
    Location:777 → 850
    PWI; domain in splicing factors
    cd12446
    Location:106 → 188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  12. XM_036157589.1 → XP_036013482.1  RNA-binding protein 25 isoform X2

    Conserved Domains (2) summary
    smart00311
    Location:759 → 832
    PWI; domain in splicing factors
    cd12446
    Location:106 → 188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  13. XM_036157588.1 → XP_036013481.1  RNA-binding protein 25 isoform X1

    Conserved Domains (2) summary
    smart00311
    Location:777 → 850
    PWI; domain in splicing factors
    cd12446
    Location:106 → 188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  14. XM_036157592.1 → XP_036013485.1  RNA-binding protein 25 isoform X3

    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Conserved Domains (2) summary
    smart00311
    Location:758 → 831
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  15. XM_030246881.2 → XP_030102741.1  RNA-binding protein 25 isoform X5

    Conserved Domains (1) summary
    smart00311
    Location:554 → 627
    PWI; domain in splicing factors

  16. XM_006516169.5 → XP_006516232.1  RNA-binding protein 25 isoform X5

    See identical proteins and their annotated locations for XP_006516232.1

    UniProtKB/Swiss-Prot
    B2RY56
    Conserved Domains (1) summary
    smart00311
    Location:554 → 627
    PWI; domain in splicing factors

  17. XM_036157587.1 → XP_036013480.1  RNA-binding protein 25 isoform X1

    Conserved Domains (2) summary
    smart00311
    Location:777 → 850
    PWI; domain in splicing factors
    cd12446
    Location:106 → 188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  18. XM_030246878.2 → XP_030102738.1  RNA-binding protein 25 isoform X3

    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Conserved Domains (2) summary
    smart00311
    Location:758 → 831
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RY56.2 GenPept UniProtKB/Swiss-Prot:B2RY56

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous