U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mrpl45 mitochondrial ribosomal protein L45 [ Mus musculus (house mouse) ]

Gene ID: 67036, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Mrpl45provided by MGI
Official Full Name
mitochondrial ribosomal protein L45provided by MGI
Primary source
MGI:MGI:1914286
See related
Ensembl:ENSMUSG00000018882 AllianceGenome:MGI:1914286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600005P05Rik
Summary
Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL45 (mitochondrial ribosomal protein L45). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 11.8), CNS E11.5 (RPKM 9.9) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 D; 11 60.95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97205749..97220746)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97314923..97329920)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene aminopeptidase puromycin sensitive Neighboring gene predicted gene 11592 Neighboring gene STARR-seq mESC enhancer starr_30592 Neighboring gene STARR-seq mESC enhancer starr_30593 Neighboring gene predicted gene, 31005 Neighboring gene STARR-seq mESC enhancer starr_30594 Neighboring gene STARR-seq mESC enhancer starr_30595 Neighboring gene predicted gene, 53647 Neighboring gene G protein-coupled receptor 179 Neighboring gene suppressor of cytokine signaling 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cardiac deletion of Smyd2 is dispensable for mouse heart development. Diehl F, et al. PLoS One, 2010 Mar 17. PMID 20305823, Free PMC Article
  2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
large ribosomal subunit protein mL45
Names
39S ribosomal protein L45, mitochondrial
L45mt
MRP-L45

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025927.4 → NP_080203.1  large ribosomal subunit protein mL45

    See identical proteins and their annotated locations for NP_080203.1

    Status: VALIDATED

    Source sequence(s)
    AK011163, AL596088, BY263659
    Consensus CDS
    CCDS25318.1
    UniProtKB/Swiss-Prot
    Q3TZL8, Q8VDW2, Q9D0Q7
    UniProtKB/TrEMBL
    Q9CSZ8
    Related
    ENSMUSP00000019026.4, ENSMUST00000019026.10
    Conserved Domains (1) summary
    pfam04280
    Location:119 → 266
    Tim44; Tim44-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97205749..97220746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314713.2 → XP_017170202.1  large ribosomal subunit protein mL45 isoform X1

    Conserved Domains (1) summary
    smart00978
    Location:119 → 322
    Tim44; Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0Q7.1 GenPept UniProtKB/Swiss-Prot:Q9D0Q7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous