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Tbc1d2b TBC1 domain family, member 2B [ Mus musculus (house mouse) ]

Gene ID: 67016, updated on 11-Apr-2024

Summary

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Official Symbol
Tbc1d2bprovided by MGI
Official Full Name
TBC1 domain family, member 2Bprovided by MGI
Primary source
MGI:MGI:1914266
See related
Ensembl:ENSMUSG00000037410 AllianceGenome:MGI:1914266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1055; 1810061M12Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in cytosol. Is expressed in genitourinary system. Orthologous to human TBC1D2B (TBC1 domain family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 19.4), mammary gland adult (RPKM 17.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.1; 9 47.48 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (90084100..90152861, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (90202047..90270772, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9030 Neighboring gene STARR-seq mESC enhancer starr_24885 Neighboring gene nuclear encoded tRNA lysine 18 (anticodon CTT) Neighboring gene RIKEN cDNA 9430062P05 gene Neighboring gene STARR-seq mESC enhancer starr_24886 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 7 Neighboring gene STARR-positive B cell enhancer ABC_E8860 Neighboring gene predicted gene 16200 Neighboring gene predicted gene, 30849 Neighboring gene predicted gene, 22717 Neighboring gene predicted gene, 22866

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TBC1 domain family member 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413795.1 → NP_001400724.1  TBC1 domain family member 2B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140392, AC151735

  2. NM_194334.3 → NP_919315.2  TBC1 domain family member 2B isoform 1

    See identical proteins and their annotated locations for NP_919315.2

    Status: VALIDATED

    Source sequence(s)
    AC140392, AC151735
    Consensus CDS
    CCDS23401.1
    UniProtKB/Swiss-Prot
    Q2VPQ4, Q3U0J8, Q6PHN8, Q6ZPZ5
    Related
    ENSMUSP00000045413.8, ENSMUST00000041767.14
    Conserved Domains (4) summary
    cd01265
    Location:36 → 144
    PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
    pfam00169
    Location:38 → 136
    PH; PH domain
    pfam00566
    Location:710 → 878
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam16515
    Location:341 → 378
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    90084100..90152861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001778980.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U0J8.2 GenPept UniProtKB/Swiss-Prot:Q3U0J8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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