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Mettl6 methyltransferase 6, methylcytidine [ Mus musculus (house mouse) ]

Gene ID: 67011, updated on 11-Apr-2024

Summary

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Official Symbol
Mettl6provided by MGI
Official Full Name
methyltransferase 6, methylcytidineprovided by MGI
Primary source
MGI:MGI:1914261
See related
Ensembl:ENSMUSG00000021891 AllianceGenome:MGI:1914261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1600013P15Rik
Summary
Enables tRNA (cytosine-3-)-methyltransferase activity. Involved in tRNA methylation. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human METTL6 (methyltransferase 6, methylcytidine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 4.3), CNS E11.5 (RPKM 4.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 B; 14 19.12 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31180775..31217007, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31463715..31495059, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32149566-32149675 Neighboring gene calpain 7 Neighboring gene SH3-domain binding protein 5 (BTK-associated) Neighboring gene STARR-seq mESC enhancer starr_36314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:32229701-32230002 Neighboring gene predicted gene, 35907 Neighboring gene STARR-positive B cell enhancer ABC_E7303 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36316 Neighboring gene ELL associated factor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32345029-32345265 Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32369012-32369287 Neighboring gene STARR-seq mESC enhancer starr_36317

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth. Ignatova VV, et al. Sci Adv, 2020 Aug. PMID 32923617, Free PMC Article
  2. Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. Xu L, et al. J Biol Chem, 2017 Sep 1. PMID 28655767, Free PMC Article
  3. Loss of maternal Trim28 causes male-predominant early embryonic lethality. Sampath Kumar A, et al. Genes Dev, 2017 Jan 1. PMID 28115466, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (cytidine-3-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA (cytidine-3-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA N(3)-methylcytidine methyltransferase METTL6
Names
methyltransferase like 6
methyltransferase-like protein 6
NP_001346775.1
NP_001346776.1
NP_001346777.1
NP_001346778.1
NP_001346779.1
NP_001361702.1
NP_080183.1
XP_011243456.1
XP_030103822.1
XP_030103823.1
XP_030103824.1
XP_030103826.1
XP_030103828.1
XP_036014717.1
XP_036014718.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359846.1 → NP_001346775.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154616, AK005448, AV241644
    Consensus CDS
    CCDS26913.1
    UniProtKB/Swiss-Prot
    Q8BVH9, Q9D9M6, Q9DAX6
    Conserved Domains (1) summary
    pfam08242
    Location:84 → 182
    Methyltransf_12; Methyltransferase domain

  2. NM_001359847.1 → NP_001346776.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154616, AK133735
    Consensus CDS
    CCDS88619.1
    UniProtKB/TrEMBL
    A0A2I3BRX7
    Related
    ENSMUSP00000154767.2, ENSMUST00000227777.2
    Conserved Domains (1) summary
    pfam08242
    Location:84 → 182
    Methyltransf_12; Methyltransferase domain

  3. NM_001359848.1 → NP_001346777.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154616, AK005448, AK006715, AV241644
    Consensus CDS
    CCDS88617.1
    Related
    ENSMUSP00000154580.2, ENSMUST00000227595.2
    Conserved Domains (1) summary
    pfam13649
    Location:70 → 137
    Methyltransf_25; Methyltransferase domain

  4. NM_001359849.1 → NP_001346778.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154616, AK005448, AV241644
    UniProtKB/TrEMBL
    A0A2I3BQ54
    Related
    ENSMUSP00000153931.2, ENSMUST00000228181.2
    Conserved Domains (2) summary
    COG2227
    Location:29 → 124
    UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]
    pfam08242
    Location:84 → 177
    Methyltransf_12; Methyltransferase domain

  5. NM_001359850.1 → NP_001346779.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154616, AK005448, AV241644
    Conserved Domains (1) summary
    pfam08242
    Location:133 → 231
    Methyltransf_12; Methyltransferase domain

  6. NM_001374773.1 → NP_001361702.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154616, AK078185
    Consensus CDS
    CCDS88618.1
    Related
    ENSMUSP00000154679.2, ENSMUST00000228727.2
    Conserved Domains (1) summary
    pfam08242
    Location:84 → 182
    Methyltransf_12; Methyltransferase domain

  7. NM_025907.4 → NP_080183.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 1

    See identical proteins and their annotated locations for NP_080183.1

    Status: VALIDATED

    Source sequence(s)
    AC154616, AK005448, AV241644
    Consensus CDS
    CCDS26913.1
    UniProtKB/Swiss-Prot
    Q8BVH9, Q9D9M6, Q9DAX6
    Related
    ENSMUSP00000077138.3, ENSMUST00000055303.5
    Conserved Domains (1) summary
    pfam08242
    Location:84 → 182
    Methyltransf_12; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31180775..31217007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247966.2 → XP_030103826.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X5

    Conserved Domains (1) summary
    pfam08242
    Location:84 → 182
    Methyltransf_12; Methyltransferase domain

  2. XM_030247968.2 → XP_030103828.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X6

    Conserved Domains (1) summary
    pfam13649
    Location:70 → 137
    Methyltransf_25; Methyltransferase domain

  3. XM_030247962.2 → XP_030103822.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X2

    Conserved Domains (1) summary
    pfam08242
    Location:133 → 231
    Methyltransf_12; Methyltransferase domain

  4. XM_036158825.1 → XP_036014718.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:76 → 132
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_036158824.1 → XP_036014717.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X1

    Conserved Domains (1) summary
    pfam08242
    Location:134 → 232
    Methyltransf_12; Methyltransferase domain

  6. XM_030247963.2 → XP_030103823.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X3

    Conserved Domains (1) summary
    pfam08242
    Location:84 → 182
    Methyltransf_12; Methyltransferase domain

  7. XM_011245154.3 → XP_011243456.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X3

    Conserved Domains (1) summary
    pfam08242
    Location:84 → 182
    Methyltransf_12; Methyltransferase domain

  8. XM_030247964.2 → XP_030103824.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X4

    Conserved Domains (1) summary
    pfam08242
    Location:134 → 232
    Methyltransf_12; Methyltransferase domain

RNA

  1. XR_874361.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVH9.2 GenPept UniProtKB/Swiss-Prot:Q8BVH9

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