Cisd2 CDGSH iron sulfur domain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cisd2provided by MGI
Official Full Name: CDGSH iron sulfur domain 2provided by MGI
Primary source: MGI:MGI:1914256
See related: Ensembl:ENSMUSG00000028165 AllianceGenome:MGI:1914256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zcd2; Naf-1; Miner1; Noxp70; 1500009M05Rik; 1500026J14Rik; 1500031D15Rik; B630006A20Rik
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity and protein homodimerization activity. Involved in autophagy of mitochondrion and multicellular organism aging. Located in endoplasmic reticulum membrane and mitochondrial outer membrane. Is expressed in central nervous system and retina. Used to study Wolfram syndrome 2. Human ortholog(s) of this gene implicated in Wolfram syndrome 2. Orthologous to human CISD2 (CDGSH iron sulfur domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 18.0), stomach adult (RPKM 11.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 62.55 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (135112173..135129194, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (135406412..135424039, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rejuvenation: Turning Back Time by Enhancing CISD2.
Title: Rejuvenation: Turning Back Time by Enhancing CISD2.
The [2Fe-2S] protein CISD2 plays a key role in preventing iron accumulation in cardiomyocytes.
Title: The [2Fe-2S] protein CISD2 plays a key role in preventing iron accumulation in cardiomyocytes.
Cisd2 plays an essential role in corneal epithelial regeneration.
Title: Cisd2 plays an essential role in corneal epithelial regeneration.
Behavioral characterization of a novel Cisd2 mutant mouse.
Title: Behavioral characterization of a novel Cisd2 mutant mouse.
Rejuvenating the Aging Heart by Enhancing the Expression of the Cisd2 Prolongevity Gene.
Title: Rejuvenating the Aging Heart by Enhancing the Expression of the Cisd2 Prolongevity Gene.
CISD2 maintains cellular homeostasis.
Title: CISD2 maintains cellular homeostasis.
Cisd2 overexpression promoted survival and alleviated the pathological defects associated with Alzheimer disease (AD). Conversely, Cisd2 deficiency accelerated AD pathogenesis. Cisd2 overexpression protected against Abeta-mediated mitochondrial damage and attenuated loss of neurons and neuronal progenitor cells.
Title: Upregulation of Cisd2 attenuates Alzheimer's-related neuronal loss in mice.
Cisd2 is essential to delaying cardiac aging and to maintaining heart functions.
Title: Cisd2 is essential to delaying cardiac aging and to maintaining heart functions.
CISD2 haploinsufficiency disrupts calcium homeostasis, causing ER stress and subsequent nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Title: CISD2 Haploinsufficiency Disrupts Calcium Homeostasis, Causes Nonalcoholic Fatty Liver Disease, and Promotes Hepatocellular Carcinoma.
These results suggest that the thermosensitive FA-loaded hydrogel could rescue Cisd2(-/-) CM from oxidative stress-induced damage and may have potential applications in the future treatment of CVD.
Title: Recovery of oxidative stress-induced damage in Cisd2-deficient cardiomyocytes by sustained release of ferulic acid from injectable hydrogel.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CDGSH iron-sulfur domain-containing protein 2

Names: mitoNEET-related 1 protein; nervous system over-expressed protein 70; nervous system overexpressed protein 70; nutrient-deprivation autophagy factor-1; zinc finger, CDGSH-type domain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025902.3 → NP_080178.1 CDGSH iron-sulfur domain-containing protein 2

See identical proteins and their annotated locations for NP_080178.1

Status: VALIDATED

Source sequence(s)

AC156618, BE944243

Consensus CDS

CCDS17856.1

UniProtKB/Swiss-Prot

Q9CQB5, Q9D0Y0

Related

ENSMUSP00000029815.8, ENSMUST00000029815.8

Conserved Domains (2) summary

smart00704
Location:81 → 119

ZnF_CDGSH; CDGSH-type zinc finger. Function unknown

pfam10660
Location:3 → 66

MitoNEET_N; Iron-containing outer mitochondrial membrane protein N-terminus