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Psmd5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 [ Mus musculus (house mouse) ]

Gene ID: 66998, updated on 5-Mar-2024

Summary

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Official Symbol
Psmd5provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5provided by MGI
Primary source
MGI:MGI:1914248
See related
Ensembl:ENSMUSG00000026869 AllianceGenome:MGI:1914248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S5b; mKIAA0072; 1500032A03Rik
Summary
Predicted to be involved in proteasome regulatory particle assembly. Part of proteasome accessory complex. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and integumental system. Orthologous to human PSMD5 (proteasome 26S subunit, non-ATPase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 25.4), liver E14.5 (RPKM 24.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 22.99 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34742099..34760983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34852087..34870965, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene F-box and WD-40 domain protein 2 Neighboring gene STARR-seq mESC enhancer starr_04267 Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene STARR-seq mESC enhancer starr_04268 Neighboring gene STARR-seq mESC enhancer starr_04269 Neighboring gene STARR-positive B cell enhancer ABC_E3369 Neighboring gene cutA divalent cation tolerance homolog-like Neighboring gene PHD finger protein 19 Neighboring gene STARR-positive B cell enhancer ABC_E1003

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PSMD5 Inactivation Promotes 26S Proteasome Assembly during Colorectal Tumor Progression. Levin A, et al. Cancer Res, 2018 Jul 1. PMID 29716915, Free PMC Article
  2. Role of S5b/PSMD5 in proteasome inhibition caused by TNF-α/NFκB in higher eukaryotes. Shim SM, et al. Cell Rep, 2012 Sep 27. PMID 22921402
  3. Mapping the murine cardiac 26S proteasome complexes. Gomes AV, et al. Circ Res, 2006 Aug 18. PMID 16857966
  4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0072

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome regulatory particle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 5
Names
26S protease subunit S5 basic
26S proteasome subunit S5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355544.1 → NP_001342473.1  26S proteasome non-ATPase regulatory subunit 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL929068
    Conserved Domains (1) summary
    pfam10508
    Location:1 → 330
    Proteasom_PSMB; Proteasome non-ATPase 26S subunit

  2. NM_080554.2 → NP_542121.2  26S proteasome non-ATPase regulatory subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_542121.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK032992, AK148284, BY449619
    Consensus CDS
    CCDS15953.1
    UniProtKB/Swiss-Prot
    A2AUB0, Q3UFV2, Q5DU49, Q8BJY1, Q8BMA9, Q8VEE9
    Related
    ENSMUSP00000028225.6, ENSMUST00000028225.12
    Conserved Domains (2) summary
    pfam10508
    Location:1 → 504
    Proteasom_PSMB; Proteasome non-ATPase 26S subunit
    sd00044
    Location:88 → 112
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34742099..34760983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319212.3 → XP_017174701.1  26S proteasome non-ATPase regulatory subunit 5 isoform X1

    Conserved Domains (1) summary
    pfam10508
    Location:1 → 275
    Proteasom_PSMB; Proteasome non-ATPase 26S subunit

  2. XM_030251975.2 → XP_030107835.1  26S proteasome non-ATPase regulatory subunit 5 isoform X1

    Conserved Domains (1) summary
    pfam10508
    Location:1 → 275
    Proteasom_PSMB; Proteasome non-ATPase 26S subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJY1.4 GenPept UniProtKB/Swiss-Prot:Q8BJY1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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