Zfp830 zinc finger protein 830 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp830provided by MGI
Official Full Name: zinc finger protein 830provided by MGI
Primary source: MGI:MGI:1914233
See related: Ensembl:ENSMUSG00000046010 AllianceGenome:MGI:1914233
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Omcg1; Ccdc16; Znf830; 2410003C20Rik
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Involved in several processes, including mitotic DNA replication checkpoint signaling; preantral ovarian follicle growth; and replication fork protection. Acts upstream of or within several processes, including blastocyst growth; intestinal epithelial structure maintenance; and mitotic DNA damage checkpoint signaling. Located in nuclear speck. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut gland; and respiratory system. Orthologous to human ZNF830 (zinc finger protein 830). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 11 C; 11 50.22 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (82655171..82658448)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (82764345..82767622)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells.
Title: Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells.
Omcg1 plays a role in the tight coupling between mRNA pathways and maintenance of genome integrity during cell cycle progression.
Title: DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency.
Omcg1 disruption results in the lengthening of M phase and it is an important regulator of the cell cycle in the preimplantation embryo.
Title: Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein.
Phenotype of knock-out mice suggests that Omcg1 (Ccdc16) is a key regulator of the cell cycle in the preimplantation mouse embryo
Title: Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV301118 (e-PCR)
- UniSTS:180281

AW048207 (e-PCR)
- UniSTS:180283

BE686220 (e-PCR)
- UniSTS:208717

D11Pas30 (e-PCR), detects polymorphism
- UniSTS:259426

NoName (e-PCR)
- UniSTS:236671

Zfp830 (e-PCR), detects polymorphism
- UniSTS:527615

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intestinal epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mitotic DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA replication checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear DNA replication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nuclear DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in preantral ovarian follicle growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 830

Names: coiled-coil domain containing 16; coiled-coil domain-containing protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.