Pole4 polymerase (DNA-directed), epsilon 4 (p12 subunit) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pole4provided by MGI
Official Full Name: polymerase (DNA-directed), epsilon 4 (p12 subunit)provided by MGI
Primary source: MGI:MGI:1914229
See related: Ensembl:ENSMUSG00000030042 AllianceGenome:MGI:1914229
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2400007P05Rik; 5830430F06Rik
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be part of epsilon DNA polymerase complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 15.6), CNS E11.5 (RPKM 12.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (82593513..82629985, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (82616532..82653043, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

Pole4 (e-PCR), detects polymorphism
- UniSTS:536596

Pole4 (e-PCR), detects polymorphism
- UniSTS:536597

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of epsilon DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA polymerase epsilon subunit 4

Names: DNA polymerase II subunit 4; DNA polymerase epsilon subunit p12

NP_001357224.1

EC 2.7.7.7

NP_080158.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370295.1 → NP_001357224.1 DNA polymerase epsilon subunit 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC159655

Conserved Domains (1) summary

COG5208
Location:38 → 113

HAP5; CCAAT-binding factor, subunit C [Transcription]
NM_025882.3 → NP_080158.1 DNA polymerase epsilon subunit 4 isoform 1

See identical proteins and their annotated locations for NP_080158.1

Status: VALIDATED

Source sequence(s)

AC159655

Consensus CDS

CCDS39524.1

UniProtKB/Swiss-Prot

Q3TJ13, Q9CQ36

UniProtKB/TrEMBL

E0CYA9

Related

ENSMUSP00000093462.6, ENSMUST00000095786.6

Conserved Domains (1) summary

cl23735
Location:41 → 104

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...