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Mrps18b mitochondrial ribosomal protein S18B [ Mus musculus (house mouse) ]

Gene ID: 66973, updated on 5-Mar-2024

Summary

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Official Symbol
Mrps18bprovided by MGI
Official Full Name
mitochondrial ribosomal protein S18Bprovided by MGI
Primary source
MGI:MGI:1914223
See related
Ensembl:ENSMUSG00000024436 AllianceGenome:MGI:1914223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S18mt-b; MRP-S18-2; 2400002C15Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; genitourinary system; heart; and liver. Orthologous to human MRPS18B (mitochondrial ribosomal protein S18B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 47.5), large intestine adult (RPKM 47.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 18.76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36221272..36227332, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35910380..35916440, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310061I04 gene Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10949 Neighboring gene predicted gene 16279 Neighboring gene STARR-seq mESC enhancer starr_42481 Neighboring gene protein phosphatase 1, regulatory subunit 10 Neighboring gene microRNA 1894 Neighboring gene STARR-seq mESC enhancer starr_42482 Neighboring gene ring-box 1, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2. Mushtaq M, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32571933, Free PMC Article
  2. The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Lavado A, et al. Dev Cell, 2018 Dec 3. PMID 30523785, Free PMC Article
  3. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
  4. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041
  5. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2.
    Title: Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein mS40
Names
28S ribosomal protein S18-2, mitochondrial
28S ribosomal protein S18b, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347380.1 → NP_001334309.1  small ribosomal subunit protein mS40 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK076033, BP770625, DV649021
    Consensus CDS
    CCDS84307.1
    UniProtKB/TrEMBL
    Q542W5
    Related
    ENSMUSP00000109412.4, ENSMUST00000113782.10

  2. NM_001361453.1 → NP_001348382.1  small ribosomal subunit protein mS40 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR974451
    UniProtKB/TrEMBL
    G3UYX8
    Related
    ENSMUSP00000134264.2, ENSMUST00000174349.8

  3. NM_001361454.1 → NP_001348383.1  small ribosomal subunit protein mS40 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974451

  4. NM_001361455.1 → NP_001348384.1  small ribosomal subunit protein mS40 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CR974451
    UniProtKB/TrEMBL
    G3UX79
    Related
    ENSMUSP00000133584.2, ENSMUST00000174807.8
    Conserved Domains (1) summary
    cl00373
    Location:109 → 139
    Ribosomal_S18; Ribosomal protein S18

  5. NM_025878.2 → NP_080154.1  small ribosomal subunit protein mS40 isoform 1

    See identical proteins and their annotated locations for NP_080154.1

    Status: VALIDATED

    Source sequence(s)
    CR974451
    Consensus CDS
    CCDS28712.1
    UniProtKB/Swiss-Prot
    Q3TLA9, Q99N84, Q9CRK0, Q9DCR8
    UniProtKB/TrEMBL
    Q3THT9, Q3TKB7
    Related
    ENSMUSP00000025305.10, ENSMUST00000025305.16
    Conserved Domains (1) summary
    pfam01084
    Location:109 → 161
    Ribosomal_S18; Ribosomal protein S18

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36221272..36227332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160747.1 → XP_036016640.1  small ribosomal subunit protein mS40 isoform X1

    Conserved Domains (1) summary
    pfam01084
    Location:22 → 67
    Ribosomal_S18; Ribosomal protein S18
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99N84.1 GenPept UniProtKB/Swiss-Prot:Q99N84

Gene LinkOut

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