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Cdca7 cell division cycle associated 7 [ Mus musculus (house mouse) ]

Gene ID: 66953, updated on 2-Apr-2024

Summary

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Official Symbol
Cdca7provided by MGI
Official Full Name
cell division cycle associated 7provided by MGI
Primary source
MGI:MGI:1914203
See related
Ensembl:ENSMUSG00000055612 AllianceGenome:MGI:1914203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JPO1; 2310021G01Rik
Summary
Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within regulation of cell population proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 3. Orthologous to human CDCA7 (cell division cycle associated 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 42.4), CNS E11.5 (RPKM 31.9) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C3; 2 43.35 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (72306540..72317237)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (72476187..72486892)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 20 Neighboring gene predicted gene, 52556 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72234732-72234933 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72235096-72235279 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72237569-72237890 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72239438-72239655 Neighboring gene STARR-seq mESC enhancer starr_04817 Neighboring gene STARR-positive B cell enhancer ABC_E9198 Neighboring gene predicted gene, 39847 Neighboring gene STARR-seq mESC enhancer starr_04819 Neighboring gene eukaryotic translation initiation factor 1, pseudogene 3 Neighboring gene predicted gene, 30069

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Heterogeneity of natural killer cell subsets in NK-1.1+ and NK-1.1- inbred mouse strains and their progeny. Morelli L, et al. Cell Immunol, 1992 Apr 15. PMID 1555248
  2. Structural basis of specific DNA binding by the transcription factor ZBTB24. Ren R, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31226215, Free PMC Article
  3. Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors. Huang YT, et al. BMC Neurosci, 2017 Jun 5. PMID 28583079, Free PMC Article
  4. The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. Osthus RC, et al. Cancer Res, 2005 Jul 1. PMID 15994934, Free PMC Article
  5. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. Hardikar S, et al. Protein Cell, 2020 Mar. PMID 31970665, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses.
    Title: CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses.
  2. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation.
    Title: The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation.
  3. The results demonstrated that the C382Y and C407G mutations in mouse ZBTB24 abolish specific DNA binding and fail to induce Cdca7 expression, modeling the events in immunodeficiency-centromeric instability-facial anomalies syndrome in humans.
    Title: Structural basis of specific DNA binding by the transcription factor ZBTB24.
  4. Pax6 normally represses Cdca7 expression in the lateral cortex and that repression of Cdca7 in cells of this region is required for their production of a normal complement of Tbr2-expressing intermediate progenitors
    Title: Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors.
  5. Transcriptome analysis identified Cdca7 as the top down-regulated gene in Zbtb24 homozygous mutant mESCs, which can be restored by ectopic ZBTB24 expression. Finally, we show that this regulation is conserved between species and that CDCA7 levels are reduced in patients carrying ZBTB24 nonsense mutations
    Title: Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell division cycle-associated protein 7
Names
c-Myc target JPO1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418560.1 → NP_001405489.1  cell division cycle-associated protein 7 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL845274

  2. NM_001418561.1 → NP_001405490.1  cell division cycle-associated protein 7 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL845274

  3. NM_001418562.1 → NP_001405491.1  cell division cycle-associated protein 7 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL845274

  4. NM_001418563.1 → NP_001405492.1  cell division cycle-associated protein 7 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL845274

  5. NM_025866.4 → NP_080142.1  cell division cycle-associated protein 7 isoform a

    See identical proteins and their annotated locations for NP_080142.1

    Status: VALIDATED

    Source sequence(s)
    AL845274
    Consensus CDS
    CCDS16121.1
    UniProtKB/Swiss-Prot
    Q3TIS1, Q3U511, Q6NZE5, Q8C1A0, Q9D0M2
    Related
    ENSMUSP00000099752.5, ENSMUST00000102691.11
    Conserved Domains (1) summary
    pfam10497
    Location:273 → 371
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

RNA

  1. NR_184782.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845274

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    72306540..72317237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0M2.1 GenPept UniProtKB/Swiss-Prot:Q9D0M2

Gene LinkOut

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