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Acad8 acyl-Coenzyme A dehydrogenase family, member 8 [ Mus musculus (house mouse) ]

Gene ID: 66948, updated on 5-Mar-2024

Summary

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Official Symbol
Acad8provided by MGI
Official Full Name
acyl-Coenzyme A dehydrogenase family, member 8provided by MGI
Primary source
MGI:MGI:1914198
See related
Ensembl:ENSMUSG00000031969 AllianceGenome:MGI:1914198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310016C19Rik
Summary
Predicted to enable acyl-CoA dehydrogenase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ACAD8 (acyl-CoA dehydrogenase family member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 8.3), genital fat pad adult (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A4; 9 12.0 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (26885434..26910872, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (26974138..26999571, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1110 Neighboring gene STARR-seq mESC enhancer starr_23615 Neighboring gene STARR-seq mESC enhancer starr_23616 Neighboring gene zinc finger CCCH type containing 11A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8282 Neighboring gene thymocyte nuclear protein 1 Neighboring gene VPS26 retromer complex component B Neighboring gene STARR-positive B cell enhancer ABC_E8283 Neighboring gene STARR-positive B cell enhancer ABC_E3819 Neighboring gene non-SMC condensin II complex, subunit D3 Neighboring gene STARR-seq mESC enhancer starr_23617

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice. Sabbagha NG, et al. Pediatr Res, 2011 Jul. PMID 21659959
  2. Mapping of genetic loci that modulate differential colonization by Escherichia coli O157:H7 TUV86-2 in advanced recombinant inbred BXD mice. Russo LM, et al. BMC Genomics, 2015 Nov 16. PMID 26573818, Free PMC Article
  3. A cellular and spatial map of the choroid plexus across brain ventricles and ages. Dani N, et al. Cell, 2021 May 27. PMID 33932339, Free PMC Article
  4. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-methylbutanoyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-methylpropanoyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within branched-chain amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
isobutyryl-CoA dehydrogenase, mitochondrial
Names
ACAD-8
acyl-CoA dehydrogenase family member 8
NP_080138.2
XP_006510613.1
XP_030100369.1
XP_030100370.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025862.2 → NP_080138.2  isobutyryl-CoA dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_080138.2

    Status: VALIDATED

    Source sequence(s)
    AC138616, AK077335, BQ931973
    Consensus CDS
    CCDS40567.1
    UniProtKB/Swiss-Prot
    Q8BK36, Q8BKQ8, Q8CFY9, Q9D2L8, Q9D7B6
    UniProtKB/TrEMBL
    A0A0R4J0P1, D3YTT4
    Related
    ENSMUSP00000054370.8, ENSMUST00000060513.8
    Conserved Domains (2) summary
    cd01162
    Location:39 → 412
    IBD; Isobutyryl-CoA dehydrogenase
    COG1960
    Location:37 → 411
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    26885434..26910872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244509.1 → XP_030100369.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q8BK36, Q8BKQ8, Q8CFY9, Q9D2L8, Q9D7B6
    UniProtKB/TrEMBL
    D3YTT4
    Conserved Domains (1) summary
    cd01162
    Location:1 → 355
    IBD; Isobutyryl-CoA dehydrogenase

  2. XM_006510550.4 → XP_006510613.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl09933
    Location:1 → 211
    ACAD; Acyl-CoA dehydrogenase

  3. XM_030244510.1 → XP_030100370.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl09933
    Location:1 → 211
    ACAD; Acyl-CoA dehydrogenase

RNA

  1. XR_870536.4 RNA Sequence

  2. XR_001778975.3 RNA Sequence

  3. XR_003947975.2 RNA Sequence

  4. XR_001778977.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7B6.2 GenPept UniProtKB/Swiss-Prot:Q9D7B6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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