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Ddx18 DEAD box helicase 18 [ Mus musculus (house mouse) ]

Gene ID: 66942, updated on 5-Mar-2024

Summary

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Official Symbol
Ddx18provided by MGI
Official Full Name
DEAD box helicase 18provided by MGI
Primary source
MGI:MGI:1914192
See related
Ensembl:ENSMUSG00000001674 AllianceGenome:MGI:1914192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310005B10Rik
Summary
Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human DDX18 (DEAD-box helicase 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.0), liver E14 (RPKM 19.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E2.3; 1 52.98 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (121481564..121495709, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (121553835..121567980, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10030 Neighboring gene coiled-coil domain containing 93 Neighboring gene STARR-seq mESC enhancer starr_02076 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 5B Neighboring gene STARR-seq mESC enhancer starr_02077 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:123504681-123504864 Neighboring gene STARR-seq mESC enhancer starr_02078 Neighboring gene STARR-seq mESC enhancer starr_02080 Neighboring gene STARR-seq mESC enhancer starr_02081 Neighboring gene STARR-seq mESC enhancer starr_02082 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 10 pseudogene Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation. Zhang H, et al. Cell Rep, 2020 Jan 7. PMID 31914400
  2. BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Mathew R, et al. Nature, 2012 Nov 22. PMID 23086144, Free PMC Article
  3. PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. Cairo S, et al. Oncogene, 2005 Mar 24. PMID 15735755
  4. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
  5. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.
    Title: DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117904

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX18
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DEAD box protein 18
NP_080136.2
XP_006529857.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025860.3 → NP_080136.2  ATP-dependent RNA helicase DDX18

    See identical proteins and their annotated locations for NP_080136.2

    Status: VALIDATED

    Source sequence(s)
    BC103776, BY084565, BY381480
    Consensus CDS
    CCDS15240.1
    UniProtKB/Swiss-Prot
    Q3MIB0, Q8BVZ2, Q8K363, Q9D2E0
    UniProtKB/TrEMBL
    B2RUM8
    Related
    ENSMUSP00000001724.6, ENSMUST00000001724.12
    Conserved Domains (5) summary
    smart00487
    Location:184 → 372
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:390 → 519
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:169 → 376
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam05177
    Location:50 → 157
    RCSD; RCSD region
    pfam13959
    Location:551 → 609
    DUF4217; Domain of unknown function (DUF4217)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    121481564..121495709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529794.5 → XP_006529857.1  ATP-dependent RNA helicase DDX18 isoform X1

    Conserved Domains (2) summary
    COG0513
    Location:95 → 508
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd17942
    Location:108 → 305
    DEADc_DDX18; DEAD-box helicase domain of DEAD box protein 18
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K363.1 GenPept UniProtKB/Swiss-Prot:Q8K363

Gene LinkOut

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