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Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 [ Mus musculus (house mouse) ]

Gene ID: 66916, updated on 5-Mar-2024

Summary

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Official Symbol
Ndufb7provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit B7provided by MGI
Primary source
MGI:MGI:1914166
See related
Ensembl:ENSMUSG00000033938 AllianceGenome:MGI:1914166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110002H15Rik
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and urinary system. Orthologous to human NDUFB7 (NADH:ubiquinone oxidoreductase subunit B7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 332.5), duodenum adult (RPKM 247.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C2; 8 40.22 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84293387..84298252)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83566758..83571623)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily K member 2 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22086 Neighboring gene STARR-positive B cell enhancer ABC_E6666 Neighboring gene RIKEN cDNA D830024N08 gene Neighboring gene trans-2,3-enoyl-CoA reductase Neighboring gene predicted gene, 51541 Neighboring gene STARR-positive B cell enhancer ABC_E454 Neighboring gene predicted gene, 42029 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics. Ponce JM, et al. J Am Heart Assoc, 2020 Apr 7. PMID 32248761, Free PMC Article
  2. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Dai N, et al. Cell Metab, 2015 Apr 7. PMID 25863250, Free PMC Article
  3. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Yavari A, et al. Cell Metab, 2016 May 10. PMID 27133129, Free PMC Article
  4. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
  5. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, et al. Essays Biochem, 2018 Jul 20. PMID 30030361, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Names
CI-B18
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
NADH-ubiquinone oxidoreductase B18 subunit
complex I-B18
NP_080119.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025843.3 → NP_080119.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

    See identical proteins and their annotated locations for NP_080119.1

    Status: VALIDATED

    Source sequence(s)
    AC151992
    Consensus CDS
    CCDS22455.1
    UniProtKB/Swiss-Prot
    Q9CR61
    Related
    ENSMUSP00000037341.6, ENSMUST00000036996.6
    Conserved Domains (1) summary
    pfam05676
    Location:41 → 100
    NDUF_B7; NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84293387..84298252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR61.3 GenPept UniProtKB/Swiss-Prot:Q9CR61

Gene LinkOut

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