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Cops9 COP9 signalosome subunit 9 [ Mus musculus (house mouse) ]

Gene ID: 66915, updated on 5-Mar-2024

Summary

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Official Symbol
Cops9provided by MGI
Official Full Name
COP9 signalosome subunit 9provided by MGI
Primary source
MGI:MGI:1914165
See related
Ensembl:ENSMUSG00000073616 AllianceGenome:MGI:1914165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myeov2; 1110002M09Rik
Summary
Predicted to be involved in several processes, including cellular response to UV; cytoplasmic sequestering of protein; and negative regulation of protein neddylation. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. Predicted to be part of COP9 signalosome. Orthologous to human COPS9 (COP9 signalosome subunit 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 43.2), CNS E14 (RPKM 40.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cops9 in Genome Data Viewer
Location:
1 D; 1 46.55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (92564867..92569707, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (92637145..92641985, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01718 Neighboring gene olfactory receptor family 9 subfamily S member 14 Neighboring gene STARR-seq mESC enhancer starr_01719 Neighboring gene STARR-seq mESC enhancer starr_01720 Neighboring gene olfactory receptor family 9 subfamily S member 13 Neighboring gene otospiralin Neighboring gene STARR-seq mESC enhancer starr_01721 Neighboring gene predicted gene 29483

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic sequestering of protein ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 9
Names
myeloma overexpressed 2
myeloma-overexpressed gene 2 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163425.1 → NP_001156897.1  COP9 signalosome complex subunit 9

    See identical proteins and their annotated locations for NP_001156897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AA764377, BC049759
    Consensus CDS
    CCDS48325.1
    UniProtKB/Swiss-Prot
    Q3U898
    UniProtKB/TrEMBL
    B2RVT1
    Related
    ENSMUSP00000095247.4, ENSMUST00000097642.4
    Conserved Domains (1) summary
    pfam15004
    Location:1 → 50
    MYEOV2; Myeloma-overexpressed-like

RNA

  1. NR_028108.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA764377, AC126600, BY631936
    Related
    ENSMUST00000148508.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    92564867..92569707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U898.1 GenPept UniProtKB/Swiss-Prot:Q3U898

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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