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Vmn2r88 vomeronasal 2, receptor 88 [ Mus musculus (house mouse) ]

Gene ID: 669149, updated on 11-Apr-2024

Summary

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Official Symbol
Vmn2r88provided by MGI
Official Full Name
vomeronasal 2, receptor 88provided by MGI
Primary source
MGI:MGI:1316662
See related
Ensembl:ENSMUSG00000000606 AllianceGenome:MGI:1316662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
V2r3; V2r13
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Vmn2r88 in Genome Data Viewer
Location:
14 C1; 14 26.51 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51648458..51656984)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51411001..51419527)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36672 Neighboring gene cyclin-dependent kinase 8 pseudogene Neighboring gene predicted gene 7247 Neighboring gene vomeronasal 2, receptor, pseudogene 110 Neighboring gene STARR-positive B cell enhancer mm9_chr14:52034327-52034627 Neighboring gene vomeronasal 2, receptor, pseudogene 111 Neighboring gene vomeronasal 2, receptor 89

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multisensory Logic of Infant-Directed Aggression by Males. Isogai Y, et al. Cell, 2018 Dec 13. PMID 30550786, Free PMC Article
  2. A multigene family encoding a diverse array of putative pheromone receptors in mammals. Matsunami H, et al. Cell, 1997 Aug 22. PMID 9288756
  3. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vomeronasal 2, receptor 88
Names
vomeronasal 2, receptor, 13
vomeronasal 2, receptor, 3
vomeronasal organ family 2, receptor, 13
vomeronasal organ family 2, receptor, 3
vomeronasal receptor Vmn2r88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368932.1 → NP_001355861.1  vomeronasal 2, receptor 88 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122858
    Consensus CDS
    CCDS88654.1
    UniProtKB/TrEMBL
    A0A3B2WCB0, F7D4U1
    Related
    ENSMUSP00000125126.3, ENSMUST00000159674.4
    Conserved Domains (3) summary
    cd06365
    Location:40 → 500
    PBP1_Pheromone_receptor; Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    cd15283
    Location:581 → 832
    7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:510 → 561
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  2. NM_001368934.1 → NP_001355863.1  vomeronasal 2, receptor 88 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122858
    Consensus CDS
    CCDS88655.1
    UniProtKB/TrEMBL
    F6U6R2, O35201
    Related
    ENSMUSP00000124837.3, ENSMUST00000163019.9
    Conserved Domains (1) summary
    cd06365
    Location:40 → 431
    PBP1_Pheromone_receptor; Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

  3. NM_001385269.1 → NP_001372198.1  vomeronasal 2, receptor 88 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122858
    UniProtKB/TrEMBL
    A0A3B2W7D8, A0A3B2WCB0
    Related
    ENSMUSP00000156456.2, ENSMUST00000233394.2
    Conserved Domains (3) summary
    cd15283
    Location:582 → 833
    7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06365
    Location:46 → 500
    PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:508 → 562
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  4. NM_001385270.1 → NP_001372199.1  vomeronasal 2, receptor 88 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122858
    UniProtKB/TrEMBL
    A0A3B2W498, O35201
    Related
    ENSMUSP00000156821.2, ENSMUST00000233766.2
    Conserved Domains (1) summary
    cl10011
    Location:46 → 432
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51648458..51656984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519400.1 → XP_006519463.1  vomeronasal 2, receptor 88 isoform X1

    UniProtKB/TrEMBL
    A0A3B2WCB0
    Conserved Domains (3) summary
    cd15283
    Location:582 → 833
    7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:517 → 562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06365
    Location:46 → 500
    PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

  2. XM_036158822.1 → XP_036014715.1  vomeronasal 2, receptor 88 isoform X4

    UniProtKB/TrEMBL
    A0A3B2WCB0
    Conserved Domains (2) summary
    cd15283
    Location:541 → 792
    7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06365
    Location:46 → 500
    PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

  3. XM_030247959.1 → XP_030103819.1  vomeronasal 2, receptor 88 isoform X2

    UniProtKB/TrEMBL
    A0A3B2WCB0
    Conserved Domains (3) summary
    cd15283
    Location:583 → 834
    7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:510 → 563
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06365
    Location:46 → 500
    PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

  4. XM_036158823.1 → XP_036014716.1  vomeronasal 2, receptor 88 isoform X5

    UniProtKB/TrEMBL
    A0A3B2WB46, A0A3B2WDD6
    Related
    ENSMUSP00000156671.2, ENSMUST00000232951.2
    Conserved Domains (2) summary
    cd15283
    Location:506 → 757
    7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:46 → 481
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

  5. XM_036158821.1 → XP_036014714.1  vomeronasal 2, receptor 88 isoform X3

    UniProtKB/TrEMBL
    A0A3B2WCB0
    Conserved Domains (3) summary
    cd15283
    Location:579 → 830
    7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06365
    Location:46 → 498
    PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:506 → 559
    NCD3G; Nine Cysteines Domain of family 3 GPCR

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011686.1: Suppressed sequence

    Description
    NM_011686.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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