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Nudt16l1 nudix hydrolase 16 like 1 [ Mus musculus (house mouse) ]

Gene ID: 66911, updated on 5-Mar-2024

Summary

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Official Symbol
Nudt16l1provided by MGI
Official Full Name
nudix hydrolase 16 like 1provided by MGI
Primary source
MGI:MGI:1914161
See related
Ensembl:ENSMUSG00000022516 AllianceGenome:MGI:1914161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sdos; syndesmos; 1110001K21Rik; 5330437I08Rik
Summary
Predicted to enable snoRNA binding activity. Predicted to be involved in negative regulation of double-strand break repair via nonhomologous end joining. Predicted to be active in nucleus. Orthologous to human NUDT16L1 (nudix hydrolase 16 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 49.1), adrenal adult (RPKM 46.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A1; 16 2.48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4756975..4758892)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4939111..4941028)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4878205-4878392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4879753-4879936 Neighboring gene STARR-positive B cell enhancer ABC_E1919 Neighboring gene UBA-like domain containing 1 Neighboring gene mahogunin, ring finger 1 Neighboring gene STARR-positive B cell enhancer mm9_chr16:4938936-4939237 Neighboring gene predicted gene, 16861 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene predicted gene, 36681 Neighboring gene dynein axonemal assembly factor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5. Denhez F, et al. J Biol Chem, 2002 Apr 5. PMID 11805099
  2. Multiple mRNA decapping enzymes in mammalian cells. Song MG, et al. Mol Cell, 2010 Nov 12. PMID 21070968, Free PMC Article
  3. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. Phan LK, et al. J Clin Invest, 2002 Nov. PMID 12438443, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables phosphodiesterase decapping endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snoRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in sno(s)RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tudor-interacting repair regulator protein
Names
NUDT16-like protein 1
nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1
protein syndesmos

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316715.1 → NP_001303644.1  tudor-interacting repair regulator protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK003241, BQ030979, CF160100
    Consensus CDS
    CCDS88870.1
    UniProtKB/Swiss-Prot
    Q8VHN8
    Related
    ENSMUSP00000054201.10, ENSMUST00000050881.10

  2. NM_025839.4 → NP_080115.1  tudor-interacting repair regulator protein isoform 1

    See identical proteins and their annotated locations for NP_080115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK003241, BQ030979
    Consensus CDS
    CCDS27927.1
    UniProtKB/Swiss-Prot
    Q3TW47, Q8R039, Q8R3D9, Q8VHN8, Q9CR90, Q9D8M0
    UniProtKB/TrEMBL
    A0A2R8VH99
    Related
    ENSMUSP00000155142.2, ENSMUST00000230931.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4756975..4758892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHN8.2 GenPept UniProtKB/Swiss-Prot:Q8VHN8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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