Plin3 perilipin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plin3provided by MGI
Official Full Name: perilipin 3provided by MGI
Primary source: MGI:MGI:1914155
See related: Ensembl:ENSMUSG00000024197 AllianceGenome:MGI:1914155
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tip47; M6prbp1; 1300012C15Rik
Summary: Predicted to be involved in lipid storage and positive regulation of sequestering of triglyceride. Predicted to be located in endosome and membrane. Predicted to be active in cytosol and lipid droplet. Is expressed in several structures, including choroid plexus; genitourinary system; gut; nasal septum; and turbinate bone primordium. Orthologous to human PLIN3 (perilipin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in small intestine adult (RPKM 176.8), duodenum adult (RPKM 150.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 29.25 cM; 17 D

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56585962..56597511, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56278962..56290511, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.
Title: Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.
Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum.
Title: Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum.
These data suggest that Plin3 acts as an intrinsic protective factor preventing futile beige adipocyte formation by limiting lipid metabolism and thermogenic gene expression.
Title: Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARα Activation.
our studies demonstrate that the lipid droplets (LDs) scaffold protein, PLIN3, is essential for HCV core-induced hepatic steatosis and provide new insights into the pathogenesis of HCV.
Title: The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.
Postprandial triglyceride rich lipoproteins may be involved in atherosclerotic plaque formation through the regulation of perilipin-2 and perilipin-3 proteins in macrophages.
Title: Postprandial triglyceride-rich lipoproteins regulate perilipin-2 and perilipin-3 lipid-droplet-associated proteins in macrophages.
Collectively these data suggest that whereas perilipin 1 potently suppresses basal lipolysis in adipocytes, perilipins 2 and 3 facilitate higher rates of basal lipolysis
Title: Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis.
Data indicate that PLIN2 and PLIN3 may participate in acute lipid droplet formation in mammalian testes.
Title: Transient scrotal hyperthermia induces lipid droplet accumulation and reveals a different ADFP expression pattern between the testes and liver in mice.
These findings show that TIP47 affects hepatic lipid and glucose metabolism and may be a target for the treatment of nonalcoholic fatty liver and related metabolic disorders.
Title: Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice.
Overexpression of tail interacting protein of 47 kDa (TIP47), but not its truncated form (t-TIP47) protected NIH3T3 cells from hydrogen-peroxide-induced cell death, prevented the hydrogen-peroxide-induced mitochondrial depolarization.
Title: TIP47 protects mitochondrial membrane integrity and inhibits oxidative-stress-induced cell death.
These results suggest distinct roles for TIP47 and adipophilin in dietary fat absorption.
Title: Differential association of adipophilin and TIP47 proteins with cytoplasmic lipid droplets in mouse enterocytes during dietary fat absorption.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet disassembly	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sequestering of triglyceride	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: perilipin-3

Names: cargo selection protein TIP47; mannose-6-phosphate receptor binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.