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Pccb propionyl Coenzyme A carboxylase, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 66904, updated on 9-May-2024

Summary

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Official Symbol
Pccbprovided by MGI
Official Full Name
propionyl Coenzyme A carboxylase, beta polypeptideprovided by MGI
Primary source
MGI:MGI:1914154
See related
Ensembl:ENSMUSG00000032527 AllianceGenome:MGI:1914154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300012P06Rik
Summary
Predicted to enable propionyl-CoA carboxylase activity. Located in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; eye; and respiratory system. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCB (propionyl-CoA carboxylase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 119.2), liver adult (RPKM 65.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E4; 9 53.09 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (100864085..100916993, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (100982032..101034940, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STAG1 cohesin complex component Neighboring gene STARR-positive B cell enhancer ABC_E6797 Neighboring gene predicted gene 8661 Neighboring gene adaptor-related protein complex 2, beta 1 subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_25043 Neighboring gene RIKEN cDNA 6720484G13 gene Neighboring gene STARR-positive B cell enhancer ABC_E11420 Neighboring gene STARR-positive B cell enhancer ABC_E2300 Neighboring gene STARR-seq mESC enhancer starr_25045 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:100965416-100965626 Neighboring gene STARR-seq mESC enhancer starr_25047 Neighboring gene brain expressed X-linked 2 pseudogene Neighboring gene predicted gene, 46140

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cDNA cloning, mapping and expression of the mouse propionyl CoA carboxylase beta (pccb), the gene for human type II propionic acidaemia. Schrick JJ, et al. Gene, 2001 Feb 7. PMID 11245989
  2. Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice. Huang S, et al. Circulation, 2019 Jun 18. PMID 30947518, Free PMC Article
  3. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
  4. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables propionyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables propionyl-CoA carboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables propionyl-CoA carboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
propionyl-CoA carboxylase beta chain, mitochondrial
Names
PCCase subunit beta
propanoyl-CoA:carbon dioxide ligase subunit beta
NP_001298078.1
NP_080111.1
XP_006511433.1
XP_036011089.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311149.1 → NP_001298078.1  propionyl-CoA carboxylase beta chain, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC134825, AK050366, AK134437, BM948065, CF948895, CO043598
    Consensus CDS
    CCDS81063.1
    UniProtKB/TrEMBL
    E9Q1J7, Q3UYS0
    Related
    ENSMUSP00000118006.2, ENSMUST00000149322.8
    Conserved Domains (2) summary
    COG4799
    Location:39 → 504
    MmdA; Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism]
    cl23717
    Location:65 → 181
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  2. NM_025835.3 → NP_080111.1  propionyl-CoA carboxylase beta chain, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_080111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC134825, AK004976, AK050366
    Consensus CDS
    CCDS23442.1
    UniProtKB/Swiss-Prot
    Q99MN9, Q9DBG2
    UniProtKB/TrEMBL
    Q7TMF4
    Related
    ENSMUSP00000035116.5, ENSMUST00000035116.12
    Conserved Domains (2) summary
    COG4799
    Location:39 → 541
    MmdA; Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism]
    cl23717
    Location:65 → 212
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    100864085..100916993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155196.1 → XP_036011089.1  propionyl-CoA carboxylase beta chain, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q3UYS0
    Conserved Domains (1) summary
    pfam01039
    Location:62 → 462
    Carboxyl_trans; Carboxyl transferase domain

  2. XM_006511370.2 → XP_006511433.1  propionyl-CoA carboxylase beta chain, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q7TMF4
    Conserved Domains (1) summary
    pfam01039
    Location:62 → 499
    Carboxyl_trans; Carboxyl transferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MN9.2 GenPept UniProtKB/Swiss-Prot:Q99MN9

Gene LinkOut

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