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Myh7b myosin, heavy chain 7B, cardiac muscle, beta [ Mus musculus (house mouse) ]

Gene ID: 668940, updated on 21-Apr-2024

Summary

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Official Symbol
Myh7bprovided by MGI
Official Full Name
myosin, heavy chain 7B, cardiac muscle, betaprovided by MGI
Primary source
MGI:MGI:3710243
See related
Ensembl:ENSMUSG00000074652 AllianceGenome:MGI:3710243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myh14
Summary
This gene encodes a myosin heavy chain. The encoded protein forms a hexamer comprised of two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. [provided by RefSeq, Jun 2013]
Expression
Biased expression in heart adult (RPKM 6.9), limb E14.5 (RPKM 3.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 77.26 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155453129..155476227)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155611243..155634307)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase short-chain family member 2 Neighboring gene acyl-CoA synthetase short-chain family member 2, opposite strand Neighboring gene glutathione synthase, opposite strand 2 Neighboring gene STARR-seq mESC enhancer starr_06145 Neighboring gene glutathione synthetase Neighboring gene STARR-positive B cell enhancer ABC_E6005 Neighboring gene microRNA 499 Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene predicted gene, 22334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:155505379-155505532 Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E10157

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy. Peter AK, et al. J Am Heart Assoc, 2019 Aug 6. PMID 31364453, Free PMC Article
  2. Early de novo DNA methylation and prolonged demethylation in the muscle lineage. Tsumagari K, et al. Epigenetics, 2013 Mar. PMID 23417056, Free PMC Article
  3. Developmental expression and cardiac transcriptional regulation of Myh7b, a third myosin heavy chain in the vertebrate heart. Warkman AS, et al. Cytoskeleton (Hoboken), 2012 May. PMID 22422726, Free PMC Article
  4. Uncoupling of expression of an intronic microRNA and its myosin host gene by exon skipping. Bell ML, et al. Mol Cell Biol, 2010 Apr. PMID 20154144, Free PMC Article
  5. Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles. Rossi AC, et al. J Physiol, 2010 Jan 15. PMID 19948655, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of CAMKK-AMPK signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cardiac myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin-7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085378.2 → NP_001078847.1  myosin-7B

    See identical proteins and their annotated locations for NP_001078847.1

    Status: REVIEWED

    Source sequence(s)
    AL844852
    Consensus CDS
    CCDS50768.1
    UniProtKB/Swiss-Prot
    A2AQP0
    Related
    ENSMUSP00000090672.6, ENSMUST00000092995.6
    Conserved Domains (6) summary
    cd14927
    Location:98 → 773
    MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
    pfam00063
    Location:87 → 773
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:853 → 1930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:33 → 71
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:1819 → 1830
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:1749 → 1830
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155453129..155476227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162500.1 → XP_036018393.1  myosin-7B isoform X7

    Conserved Domains (2) summary
    pfam01576
    Location:624 → 1701
    Myosin_tail_1; Myosin tail
    cl22853
    Location:1 → 544
    Motor_domain; Myosin and Kinesin motor domain

  2. XM_017319211.3 → XP_017174700.1  myosin-7B isoform X8

    Conserved Domains (3) summary
    cd14927
    Location:98 → 773
    MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
    pfam01576
    Location:853 → 1930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:32 → 71
    Myosin_N; Myosin N-terminal SH3-like domain

  3. XM_017319206.3 → XP_017174695.1  myosin-7B isoform X1

    Conserved Domains (2) summary
    cl22853
    Location:13 → 569
    Motor_domain; Myosin and Kinesin motor domain
    pfam01576
    Location:649 → 1653
    Myosin_tail_1; Myosin tail

  4. XM_017319208.3 → XP_017174697.1  myosin-7B isoform X3

    Conserved Domains (2) summary
    cl22853
    Location:13 → 569
    Motor_domain; Myosin and Kinesin motor domain
    pfam01576
    Location:649 → 1625
    Myosin_tail_1; Myosin tail

  5. XM_017319207.3 → XP_017174696.1  myosin-7B isoform X2

    Conserved Domains (2) summary
    cl22853
    Location:1 → 544
    Motor_domain; Myosin and Kinesin motor domain
    pfam01576
    Location:624 → 1628
    Myosin_tail_1; Myosin tail

  6. XM_017319210.3 → XP_017174699.1  myosin-7B isoform X5

    Conserved Domains (2) summary
    cl22853
    Location:1 → 471
    Motor_domain; Myosin and Kinesin motor domain
    pfam01576
    Location:551 → 1555
    Myosin_tail_1; Myosin tail

  7. XM_006500047.5 → XP_006500110.1  myosin-7B isoform X2

    Conserved Domains (2) summary
    cl22853
    Location:1 → 544
    Motor_domain; Myosin and Kinesin motor domain
    pfam01576
    Location:624 → 1628
    Myosin_tail_1; Myosin tail

  8. XM_017319209.3 → XP_017174698.1  myosin-7B isoform X4

    Conserved Domains (2) summary
    cl22853
    Location:13 → 569
    Motor_domain; Myosin and Kinesin motor domain
    pfam01576
    Location:649 → 1754
    Myosin_tail_1; Myosin tail

  9. XM_036162499.1 → XP_036018392.1  myosin-7B isoform X6

    Conserved Domains (2) summary
    pfam01576
    Location:649 → 1726
    Myosin_tail_1; Myosin tail
    cl22853
    Location:13 → 569
    Motor_domain; Myosin and Kinesin motor domain

RNA

  1. XR_001783165.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AQP0.1 GenPept UniProtKB/Swiss-Prot:A2AQP0

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