Rad21l RAD21-like (S. pombe) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rad21lprovided by MGI
Official Full Name: RAD21-like (S. pombe)provided by MGI
Primary source: MGI:MGI:3652039
See related: Ensembl:ENSMUSG00000074704 AllianceGenome:MGI:3652039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm14160; Rad21l1; MeiRAD21L
Summary: Predicted to enable chromatin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; homologous chromosome segregation; and seminiferous tubule development. Located in lateral element. Part of nuclear meiotic cohesin complex. Is expressed in brain; gonad; and metanephros. Orthologous to human RAD21L1 (RAD21 cohesin complex component like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 74.83 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (151486286..151512542, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (151644366..151670622, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

when ectopically expressed in somatic cells, can promote homologous chromosome adjacency, which resembles the homolog pairing normally seen during meiosis
Title: Ectopic expression of meiotic cohesin RAD21L promotes adjacency of homologous chromosomes in somatic cells.
Our genetic analysis demonstrates that cohesins containing STAG3 and REC8 are the main complex required for centromeric cohesion, and RAD21L cohesins are required for normal clustering of pericentromeric heterochromatin. Furthermore, the STAG3/REC8 and STAG3/RAD21L cohesins are the primary cohesins required for axis formation.
Title: Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L.
These results strongly support the previous proposition that RAD21L is an atypical cohesin that establishes the association between homologs rather than sister chromatids.
Title: Meiotic cohesin subunits RAD21L and REC8 are positioned at distinct regions between lateral elements and transverse filaments in the synaptonemal complex of mouse spermatocytes.
super resolution microscopy revealed synapsis-associated SYCP1 aberrantly deposited between sister chromatids and on single chromatids in Smc1b-/-Rad21L-/- cells.
Title: Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis.
Disruption of meiosis-specific cohesin RAD21L precludes the initial association of homologs as well as the subsequent pairing in spermatocytes
Title: Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes.
RAD21L is identified as a novel subunit of the cohesin complex with homology to the RAD21/REC8/alpha-kleisin subfamily expressed in mouse testis.
Title: Identification and molecular characterization of the mammalian α-kleisin RAD21L.
These results provide in vivo evidence that RAD21L is essential for male fertility and in females for the maintenance of fertility during natural aging.
Title: The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility.
study identifes a new mammalian cohesin subunit, RAD21L, with sequence similarity to RAD21 and REC8; RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21
Title: A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing.
The results suggest that cohesin complexes containing RAD21L may be involved in synapsis initiation and crossover recombination between homologous chromosomes.
Title: RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in replication-born double-strand break repair via sister chromatid exchange	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within seminiferous tubule development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptonemal complex assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of cohesin complex	IEA Inferred from Electronic Annotation more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	IDA Inferred from Direct Assay more info	PubMed
part_of meiotic cohesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of meiotic cohesin complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: double-strand-break repair protein rad21-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276400.1 → NP_001263329.1 double-strand-break repair protein rad21-like protein 1

See identical proteins and their annotated locations for NP_001263329.1

Status: VALIDATED

Source sequence(s)

AB602048

Consensus CDS

CCDS50747.2

UniProtKB/Swiss-Prot

A2AU37, E5RTP6, F6KST0

UniProtKB/TrEMBL

R4GML2

Related

ENSMUSP00000136918.2, ENSMUST00000180195.8

Conserved Domains (2) summary

pfam04824
Location:498 → 549

Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein

pfam04825
Location:1 → 100

Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

151486286..151512542 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500044.2 → XP_006500107.1 double-strand-break repair protein rad21-like protein 1 isoform X2

UniProtKB/TrEMBL

R4GML2

Conserved Domains (2) summary

pfam04824
Location:497 → 548

Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein

pfam04825
Location:1 → 100

Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
XM_006500042.2 → XP_006500105.1 double-strand-break repair protein rad21-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006500105.1

UniProtKB/Swiss-Prot

A2AU37, E5RTP6, F6KST0

UniProtKB/TrEMBL

R4GML2

Conserved Domains (2) summary

pfam04824
Location:498 → 549

Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein

pfam04825
Location:1 → 100

Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
XM_006500043.2 → XP_006500106.1 double-strand-break repair protein rad21-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006500106.1

UniProtKB/Swiss-Prot

A2AU37, E5RTP6, F6KST0

UniProtKB/TrEMBL

R4GML2

Conserved Domains (2) summary

pfam04824
Location:498 → 549

Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein

pfam04825
Location:1 → 100

Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001114677.1: Suppressed sequence

Description

NM_001114677.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.