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Lonp2 lon peptidase 2, peroxisomal [ Mus musculus (house mouse) ]

Gene ID: 66887, updated on 5-Mar-2024

Summary

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Official Symbol
Lonp2provided by MGI
Official Full Name
lon peptidase 2, peroxisomalprovided by MGI
Primary source
MGI:MGI:1914137
See related
Ensembl:ENSMUSG00000047866 AllianceGenome:MGI:1914137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lonp; 1300002A08Rik
Summary
Predicted to enable peptidase activity and protease binding activity. Predicted to be involved in protein processing; protein targeting to peroxisome; and regulation of fatty acid beta-oxidation. Predicted to act upstream of or within proteolysis. Located in cytoplasm and nucleus. Is expressed in future brain; future prosencephalon; head; neural tube; and remnant of Rathke's pouch. Orthologous to human LONP2 (lon peptidase 2, peroxisomal). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 67.2), mammary gland adult (RPKM 34.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C3; 8 42.1 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (87350672..87443264)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (86624043..86716636)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24490 Neighboring gene STARR-seq mESC enhancer starr_22180 Neighboring gene STARR-seq mESC enhancer starr_22182 Neighboring gene ATP-binding cassette, sub-family C member 12 Neighboring gene STARR-positive B cell enhancer ABC_E10515 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:89230711-89230912 Neighboring gene predicted gene, 22305 Neighboring gene STARR-seq mESC enhancer starr_22187 Neighboring gene siah E3 ubiquitin protein ligase 1A Neighboring gene STARR-seq mESC enhancer starr_22189 Neighboring gene predicted gene 10638 Neighboring gene predicted gene, 39215

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DNMT1 interacts with the developmental transcriptional repressor HESX1. Sajedi E, et al. Biochim Biophys Acta, 2008 Jan. PMID 17931718, Free PMC Article
  2. In silico QTL mapping of basal liver iron levels in inbred mouse strains. McLachlan S, et al. Physiol Genomics, 2011 Feb 11. PMID 21062905, Free PMC Article
  3. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article
  4. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
  5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to peroxisome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lon protease homolog 2, peroxisomal
Names
lon protease 2
lon protease-like protein 2
peroxisomal Lon protease homolog 2
NP_001162063.1
NP_080103.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168591.1 → NP_001162063.1  lon protease homolog 2, peroxisomal isoform 2

    See identical proteins and their annotated locations for NP_001162063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK075719, BC049090
    Consensus CDS
    CCDS52624.1
    UniProtKB/TrEMBL
    Q8BK80
    Related
    ENSMUSP00000113381.2, ENSMUST00000121673.8
    Conserved Domains (2) summary
    pfam00004
    Location:1 → 93
    AAA; ATPase family associated with various cellular activities (AAA)
    cl21678
    Location:209 → 417
    ChlI; Subunit ChlI of Mg-chelatase

  2. NM_025827.3 → NP_080103.1  lon protease homolog 2, peroxisomal isoform 1

    See identical proteins and their annotated locations for NP_080103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132147, BC049090
    Consensus CDS
    CCDS22503.1
    UniProtKB/Swiss-Prot
    Q3TEG8, Q3TFY6, Q3TGR0, Q3UAE1, Q9DBN5
    Related
    ENSMUSP00000034141.12, ENSMUST00000034141.18
    Conserved Domains (4) summary
    COG0466
    Location:11 → 838
    Lon; ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]
    cl19481
    Location:4 → 202
    LON; Found in ATP-dependent protease La (LON)
    pfam00004
    Location:371 → 513
    AAA; ATPase family associated with various cellular activities (AAA)
    cl21678
    Location:629 → 837
    ChlI; Subunit ChlI of Mg-chelatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    87350672..87443264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBN5.1 GenPept UniProtKB/Swiss-Prot:Q9DBN5

Gene LinkOut

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