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Pcyox1 prenylcysteine oxidase 1 [ Mus musculus (house mouse) ]

Gene ID: 66881, updated on 5-Mar-2024

Summary

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Official Symbol
Pcyox1provided by MGI
Official Full Name
prenylcysteine oxidase 1provided by MGI
Primary source
MGI:MGI:1914131
See related
Ensembl:ENSMUSG00000029998 AllianceGenome:MGI:1914131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PCL1; Pcly; 1200015P13Rik
Summary
Enables prenylcysteine oxidase activity. Acts upstream of or within prenylcysteine catabolic process. Located in lysosome. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and respiratory system. Orthologous to human PCYOX1 (prenylcysteine oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 36.9), placenta adult (RPKM 35.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D1; 6 37.69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86362988..86374132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86386006..86397150, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4839 Neighboring gene small nuclear ribonucleoprotein polypeptide G Neighboring gene predicted gene, 52865 Neighboring gene STARR-positive B cell enhancer ABC_E11322 Neighboring gene STARR-seq mESC enhancer starr_16526 Neighboring gene nuclear encoded tRNA glycine 4 (anticodon CCC) Neighboring gene cytotoxic granule-associated RNA binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis. Banfi C, et al. Int J Mol Sci, 2022 Mar 4. PMID 35269975, Free PMC Article
  2. Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. Beigneux A, et al. J Biol Chem, 2002 Oct 11. PMID 12151402
  3. Prenylcysteine oxidase 1, an emerging player in atherosclerosis. Banfi C, et al. Commun Biol, 2021 Sep 21. PMID 34548610, Free PMC Article
  4. Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Danyukova T, et al. Hum Mol Genet, 2018 May 15. PMID 29514215, Free PMC Article
  5. Proteome-wide characterization of N-glycosylation events by diagonal chromatography. Ghesquière B, et al. J Proteome Res, 2006 Sep. PMID 16944957

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prenylcysteine oxidase 1, an emerging player in atherosclerosis.
    Title: Prenylcysteine oxidase 1, an emerging player in atherosclerosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables prenylcysteine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prenylcysteine oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables prenylcysteine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in prenylated protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prenylated protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within prenylcysteine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in prenylcysteine catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
prenylcysteine oxidase 1
Names
prenylcysteine lyase
NP_001342616.1
NP_080099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355687.1 → NP_001342616.1  prenylcysteine oxidase 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153374, AC155947
    UniProtKB/TrEMBL
    Q99JK4
    Conserved Domains (1) summary
    pfam07156
    Location:61 → 425
    Prenylcys_lyase; Prenylcysteine lyase

  2. NM_025823.4 → NP_080099.1  prenylcysteine oxidase 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080099.1

    Status: VALIDATED

    Source sequence(s)
    AK004799, AK134528
    Consensus CDS
    CCDS20311.1
    UniProtKB/Swiss-Prot
    Q3UHV6, Q69ZW0, Q8BZX1, Q9CQF9
    UniProtKB/TrEMBL
    Q3TVT6, Q3UYP2
    Related
    ENSMUSP00000032065.9, ENSMUST00000032065.15
    Conserved Domains (2) summary
    pfam07156
    Location:130 → 494
    Prenylcys_lyase; Prenylcysteine lyase
    pfam13450
    Location:39 → 106
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    86362988..86374132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQF9.1 GenPept UniProtKB/Swiss-Prot:Q9CQF9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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