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Riok3 RIO kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 66878, updated on 21-Apr-2024

Summary

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Official Symbol
Riok3provided by MGI
Official Full Name
RIO kinase 3provided by MGI
Primary source
MGI:MGI:1914128
See related
Ensembl:ENSMUSG00000024404 AllianceGenome:MGI:1914128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sudd; D18Ertd331e; 1200013N13Rik; E130306C24Rik
Summary
Predicted to enable caspase binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to organic cyclic compound; negative regulation of intracellular signal transduction; and positive regulation of interferon-beta production. Predicted to act upstream of or within defense response to other organism; phosphorylation; and ribosome biogenesis. Predicted to be located in cytoplasm. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol. Is expressed in ganglia; sensory organ; trigeminal nerve; and vibrissa. Orthologous to human RIOK3 (RIO kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 11.9), CNS E11.5 (RPKM 11.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 A1; 18 6.15 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12259114..12290424)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12126091..12157367)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 241 Neighboring gene STARR-seq mESC enhancer starr_43825 Neighboring gene STARR-seq mESC enhancer starr_43827 Neighboring gene STARR-seq mESC enhancer starr_43828 Neighboring gene STARR-seq mESC enhancer starr_43830 Neighboring gene STARR-positive B cell enhancer ABC_E4239 Neighboring gene predicted gene, 41667 Neighboring gene STARR-positive B cell enhancer ABC_E3223 Neighboring gene predicted gene, 25289 Neighboring gene predicted gene, 19293 Neighboring gene regulator of MON1-CCZ1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1. Zhang L, et al. Genes Dev, 2011 Jan 15. PMID 21196494, Free PMC Article
  2. The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. LaRonde-LeBlanc N, et al. Biochim Biophys Acta, 2005 Dec 30. PMID 16182620
  3. Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation. Shen Y, et al. Cell Rep, 2021 Jun 22. PMID 34161773, Free PMC Article
  4. Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Darakhshan F, et al. Carcinogenesis, 2006 Feb. PMID 16093251
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RIOK3 potentially regulates osteogenesis-related pathways in ankylosing spondylitis and the differentiation of bone marrow mesenchymal stem cells.
    Title: RIOK3 potentially regulates osteogenesis-related pathways in ankylosing spondylitis and the differentiation of bone marrow mesenchymal stem cells.
  2. Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
    Title: Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
  3. down-regulation of miR-191 is essential for erythroid chromatin condensation and enucleation by allowing up-regulation of Riok3 and Mxi1
    Title: miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables caspase binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to dsDNA ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to dsRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, small subunit precursor ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase RIO3
Names
sudD, suppressor of bimD6 homolog
NP_077144.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024182.4 → NP_077144.2  serine/threonine-protein kinase RIO3

    See identical proteins and their annotated locations for NP_077144.2

    Status: PROVISIONAL

    Source sequence(s)
    AK147074
    Consensus CDS
    CCDS29062.1
    UniProtKB/Swiss-Prot
    Q3UI51, Q8CIC1, Q9DBU3
    UniProtKB/TrEMBL
    Q3TJT2, Q3UYW1, Q3V2R6
    Related
    ENSMUSP00000025270.7, ENSMUST00000025270.8
    Conserved Domains (2) summary
    COG1718
    Location:214 → 461
    RIO1; Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]
    cd05146
    Location:253 → 453
    RIO3_euk; Catalytic domain of the atypical protein serine kinase, RIO3 kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    12259114..12290424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001782390.3 RNA Sequence

  2. XR_003952538.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBU3.3 GenPept UniProtKB/Swiss-Prot:Q9DBU3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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