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Mrgpra9 MAS-related GPR, member A9 [ Mus musculus (house mouse) ]

Gene ID: 668725, updated on 8-Feb-2024

Summary

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Official Symbol
Mrgpra9provided by MGI
Official Full Name
MAS-related GPR, member A9provided by MGI
Primary source
MGI:MGI:3033148
See related
Ensembl:ENSMUSG00000074111 AllianceGenome:MGI:3033148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MrgA9; mAde2R; EG668725
Summary
Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; mast cell degranulation; and positive regulation of cytokinesis. Orthologous to several human genes including MRGPRX1 (MAS related GPR family member X1); MRGPRX2 (MAS related GPR family member X2); and MRGPRX3 (MAS related GPR family member X3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Mrgpra9 in Genome Data Viewer
Location:
7 B3; 7 30.76 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46884667..46902627, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (47234919..47252879, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member A6 Neighboring gene MAS-related GPR, member A1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18881 Neighboring gene MAS-related GPR, member X3, pseudogene Neighboring gene MAS-related GPR, member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain. von Kügelgen I, et al. Mol Pharmacol, 2008 Feb. PMID 17975009
  2. Characterization of new G protein-coupled adenine receptors in mouse and hamster. Thimm D, et al. Purinergic Signal, 2013 Sep. PMID 23608776, Free PMC Article
  3. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Han SK, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12397184, Free PMC Article
  4. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong X, et al. Cell, 2001 Sep 7. PMID 11551509
  5. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12909716, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC668725
Names
G-protein coupled adenine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288801.2 → NP_001275730.1  uncharacterized protein LOC668725

    Status: VALIDATED

    Source sequence(s)
    AC115898, AC163020
    Consensus CDS
    CCDS57550.2
    UniProtKB/TrEMBL
    A0A140T8U8, L7N225
    Related
    ENSMUSP00000136396.3, ENSMUST00000179005.3
    Conserved Domains (1) summary
    pfam00001
    Location:57 → 289
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46884667..46902627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177566.1: Suppressed sequence

    Description
    NM_001177566.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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