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Plbd1 phospholipase B domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 66857, updated on 11-Apr-2024

Summary

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Official Symbol
Plbd1provided by MGI
Official Full Name
phospholipase B domain containing 1provided by MGI
Primary source
MGI:MGI:1914107
See related
Ensembl:ENSMUSG00000030214 AllianceGenome:MGI:1914107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1100001H23Rik
Summary
Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in 4th ventricle lateral recess; epidermis; and vibrissa. Orthologous to human PLBD1 (phospholipase B domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 22.6), testis adult (RPKM 20.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G1; 6 66.59 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136589069..136639301, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136612071..136662303, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136440301-136440484 Neighboring gene STARR-seq mESC enhancer starr_17596 Neighboring gene ribosomal protein L36A, pseudogene 3 Neighboring gene predicted gene, 44140 Neighboring gene STARR-positive B cell enhancer ABC_E691 Neighboring gene STARR-positive B cell enhancer ABC_E9106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136480481-136480679 Neighboring gene STARR-seq mESC enhancer starr_17599 Neighboring gene activating transcription factor 7 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E9282 Neighboring gene STARR-positive B cell enhancer ABC_E1715 Neighboring gene STARR-positive B cell enhancer ABC_E10415 Neighboring gene STARR-seq mESC enhancer starr_17605 Neighboring gene STARR-positive B cell enhancer ABC_E4875 Neighboring gene predicted gene, 40409 Neighboring gene protein S100-A10 pseudogene Neighboring gene guanylate cyclase 2c Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136692382-136692565

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
  2. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipase B-like 1
Names
LAMA-like protein 1
lamina ancestor homolog 1
phospholipase B domain-containing protein 1
putative phospholipase B-like 1
NP_080082.1
XP_006506548.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025806.2 → NP_080082.1  phospholipase B-like 1 precursor

    See identical proteins and their annotated locations for NP_080082.1

    Status: VALIDATED

    Source sequence(s)
    AC134474, AK003169
    Consensus CDS
    CCDS20652.1
    UniProtKB/Swiss-Prot
    Q3TA89, Q8VCI0, Q9D1S0
    UniProtKB/TrEMBL
    A0A0R4J0B2
    Related
    ENSMUSP00000032336.5, ENSMUST00000032336.7
    Conserved Domains (1) summary
    pfam04916
    Location:28 → 545
    Phospholip_B; Phospholipase B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    136589069..136639301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506485.5 → XP_006506548.1  phospholipase B-like 1 isoform X1

    Conserved Domains (1) summary
    pfam04916
    Location:29 → 283
    Phospholip_B; Phospholipase B
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCI0.1 GenPept UniProtKB/Swiss-Prot:Q8VCI0

Gene LinkOut

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