U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Etfdh electron transferring flavoprotein, dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 66841, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Etfdhprovided by MGI
Official Full Name
electron transferring flavoprotein, dehydrogenaseprovided by MGI
Primary source
MGI:MGI:106100
See related
Ensembl:ENSMUSG00000027809 AllianceGenome:MGI:106100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610010I20Rik
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity; electron-transferring-flavoprotein dehydrogenase activity; and ubiquinone binding activity. Involved in response to oxidative stress. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 102.8), liver adult (RPKM 55.1) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 E3; 3 34.91 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79511095..79536074, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79603788..79628767, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 2 Neighboring gene STARR-seq mESC enhancer starr_08000 Neighboring gene folliculin interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_08002 Neighboring gene RIKEN cDNA 4930589L23 gene Neighboring gene STARR-seq mESC enhancer starr_08006 Neighboring gene RIKEN cDNA 4930579G24 gene Neighboring gene peptidylprolyl isomerase D (cyclophilin D) Neighboring gene relaxin/insulin-like family peptide receptor 1 Neighboring gene STARR-seq mESC enhancer starr_08007 Neighboring gene VISTA enhancer mm1650

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection. Beites T, et al. Nat Commun, 2021 Nov 15. PMID 34782606, Free PMC Article
  2. Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice. Chen Y, et al. Free Radic Biol Med, 2006 Nov 1. PMID 17023274
  3. Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice. Mathews CE, et al. Free Radic Biol Med, 2002 Apr 15. PMID 11937300
  4. PHOG, a candidate gene for involvement in the short stature of Turner syndrome. Ellison JW, et al. Hum Mol Genet, 1997 Aug. PMID 9259282
  5. Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8. Lutz CM, et al. Genomics, 1997 May 1. PMID 9169155

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.
    Title: Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables iron-sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables quinone binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquinone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in electron transport chain ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial electron transfer flavoprotein complex TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
Names
ETF dehydrogenase
ETF-QO
ETF-ubiquinone oxidoreductase
NP_080070.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025794.2 → NP_080070.2  electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_080070.2

    Status: VALIDATED

    Source sequence(s)
    AK141684, AK152624, BE848473
    Consensus CDS
    CCDS17418.1
    UniProtKB/Swiss-Prot
    Q3U7K2, Q8BK82, Q921G7, Q9DCT9
    UniProtKB/TrEMBL
    Q6PF96
    Related
    ENSMUSP00000029386.8, ENSMUST00000029386.14
    Conserved Domains (3) summary
    COG0644
    Location:66 → 528
    FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
    pfam05187
    Location:511 → 614
    ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
    cl21454
    Location:67 → 261
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    79511095..79536074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921G7.1 GenPept UniProtKB/Swiss-Prot:Q921G7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous