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Kif26a kinesin family member 26A [ Mus musculus (house mouse) ]

Gene ID: 668303, updated on 5-Mar-2024

Summary

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Official Symbol
Kif26aprovided by MGI
Official Full Name
kinesin family member 26Aprovided by MGI
Primary source
MGI:MGI:2447072
See related
Ensembl:ENSMUSG00000021294 AllianceGenome:MGI:2447072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1236
Summary
Enables microtubule binding activity. Involved in enteric nervous system development; negative regulation of signal transduction; and regulation of cell growth by extracellular stimulus. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in central nervous system; ganglia; and intestine. Orthologous to human KIF26A (kinesin family member 26A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 14.0), whole brain E14.5 (RPKM 13.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 61.14 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112109378..112148181)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112143974..112181747)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene microRNA 3073a Neighboring gene microRNA 3073b Neighboring gene asparaginase Neighboring gene microRNA 203b Neighboring gene microRNA 203 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33350 Neighboring gene predicted gene, 36894

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice. Ohara Y, et al. Sci Rep, 2021 Feb 4. PMID 33542431, Free PMC Article
  2. KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon. Almannai M, et al. Hum Genet, 2023 Mar. PMID 36564622
  3. Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis. Qian X, et al. Dev Cell, 2022 Oct 24. PMID 36228617, Free PMC Article
  4. The Atypical Kinesin KIF26A Facilitates Termination of Nociceptive Responses by Sequestering Focal Adhesion Kinase. Wang L, et al. Cell Rep, 2018 Sep 11. PMID 30208315
  5. KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. Zhou R, et al. Cell, 2009 Nov 13. PMID 19914172

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon.
    Title: KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon.
  2. Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.
    Title: Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.
  3. Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice.
    Title: Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice.
  4. Mice with a homozygous deletion of Kif26a developed a megacolon with enteric nerve hyperplasia. Kif26a-/- enteric neurons showed hypersensitivity for GDNF-Ret signaling
    Title: KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • KIAA1236

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cerebral cortex development ISO
Inferred from Sequence Orthology
more info
  
involved_in enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell growth by extracellular stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF26A
Names
N-11 kinesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097621.1 → NP_001091090.1  kinesin-like protein KIF26A

    See identical proteins and their annotated locations for NP_001091090.1

    Status: VALIDATED

    Source sequence(s)
    BC059062, BC094358, BM963109, CB518589, CB520233, CD348409, CD350871, CD352284, CJ130134
    Consensus CDS
    CCDS49186.1
    UniProtKB/Swiss-Prot
    C9EF47, Q52KG5, Q6PCY3, Q6ZPV4, Q99PT4
    Related
    ENSMUSP00000119482.2, ENSMUST00000128402.3
    Conserved Domains (2) summary
    smart00129
    Location:365 → 725
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00106
    Location:364 → 716
    KISc; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    112109378..112148181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516162.4 → XP_006516225.1  kinesin-like protein KIF26A isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:1154 → 1647
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:869 → 1301
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00106
    Location:396 → 748
    KISc; Kinesin motor domain

  2. XM_036157581.1 → XP_036013474.1  kinesin-like protein KIF26A isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:860 → 1353
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:575 → 1007
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00106
    Location:102 → 454
    KISc; Kinesin motor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q52KG5.2 GenPept UniProtKB/Swiss-Prot:Q52KG5

Gene LinkOut

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