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Ttc1 tetratricopeptide repeat domain 1 [ Mus musculus (house mouse) ]

Gene ID: 66827, updated on 5-Mar-2024

Summary

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Official Symbol
Ttc1provided by MGI
Official Full Name
tetratricopeptide repeat domain 1provided by MGI
Primary source
MGI:MGI:1914077
See related
Ensembl:ENSMUSG00000041278 AllianceGenome:MGI:1914077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TPR1; 4833412C19Rik
Summary
Predicted to be located in cytosol. Orthologous to human TTC1 (tetratricopeptide repeat domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 16.8), bladder adult (RPKM 16.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ttc1 in Genome Data Viewer
Location:
11 B1.1; 11 25.81 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43620833..43638835, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43730006..43748008, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29265 Neighboring gene STARR-positive B cell enhancer ABC_E75 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29267 Neighboring gene predicted gene, 34963 Neighboring gene PWWP domain containing 2A Neighboring gene STARR-seq mESC enhancer starr_29268 Neighboring gene STARR-positive B cell enhancer ABC_E1414 Neighboring gene adrenergic receptor, alpha 1b Neighboring gene STARR-seq mESC enhancer starr_29271 Neighboring gene predicted gene 12153

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 1
Names
TPR repeat protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133795.2 → NP_598556.1  tetratricopeptide repeat protein 1

    See identical proteins and their annotated locations for NP_598556.1

    Status: VALIDATED

    Source sequence(s)
    AL669911, AL732633
    Consensus CDS
    CCDS24561.1
    UniProtKB/Swiss-Prot
    Q3TLM0, Q91Z38
    UniProtKB/TrEMBL
    Q3TDF3
    Related
    ENSMUSP00000040779.3, ENSMUST00000048578.3
    Conserved Domains (4) summary
    smart00028
    Location:189 → 221
    TPR; Tetratricopeptide repeats
    sd00006
    Location:119 → 144
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:158 → 188
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:119 → 186
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    43620833..43638835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Z38.1 GenPept UniProtKB/Swiss-Prot:Q91Z38

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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