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Rnf186 ring finger protein 186 [ Mus musculus (house mouse) ]

Gene ID: 66825, updated on 21-Apr-2024

Summary

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Official Symbol
Rnf186provided by MGI
Official Full Name
ring finger protein 186provided by MGI
Primary source
MGI:MGI:1914075
See related
Ensembl:ENSMUSG00000070661 AllianceGenome:MGI:1914075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130020G10Rik
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver and biliary system; and musculoskeletal system. Orthologous to human RNF186 (ring finger protein 186). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 70.57 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138694430..138695676)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138967119..138968365)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1040 Neighboring gene predicted gene, 33011 Neighboring gene predicted gene, 52684 Neighboring gene predicted gene, 42333 Neighboring gene transmembrane and coiled-coil domains 4 Neighboring gene predicted gene, 33214 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNF186 impairs insulin sensitivity by inducing ER stress in mouse primary hepatocytes. Tong X, et al. Cell Signal, 2018 Dec. PMID 30223017
  2. Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Fujimoto K, et al. Mucosal Immunol, 2017 Mar. PMID 27381925
  3. HGF Secreted by Menstrual Blood-Derived Endometrial Stem Cells Ameliorates Non-Alcoholic Fatty Liver Disease Through Downregulation of Hepatic Rnf186. Du J, et al. Stem Cells, 2023 Mar 2. PMID 36573461
  4. The role and mechanism of action of RNF186 in colorectal cancer through negative regulation of NF-κB. Ji Y, et al. Cell Signal, 2020 Nov. PMID 32882406
  5. RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells. Zhang H, et al. J Immunol, 2022 Nov 1. PMID 36130827, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
    Title: Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
  2. HGF Secreted by Menstrual Blood-Derived Endometrial Stem Cells Ameliorates Non-Alcoholic Fatty Liver Disease Through Downregulation of Hepatic Rnf186.
    Title: HGF Secreted by Menstrual Blood-Derived Endometrial Stem Cells Ameliorates Non-Alcoholic Fatty Liver Disease Through Downregulation of Hepatic Rnf186.
  3. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
    Title: RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
  4. The role and mechanism of action of RNF186 in colorectal cancer through negative regulation of NF-kappaB.
    Title: The role and mechanism of action of RNF186 in colorectal cancer through negative regulation of NF-κB.
  5. The results of the current study reveal that RNF186 triggers endoplasmic reticulum stress in mouse primary hepatocytes.
    Title: RNF186 impairs insulin sensitivity by inducing ER stress in mouse primary hepatocytes.
  6. RNF186 maintains gut homeostasis by controlling endoplasmic reticulum stress in colonic epithelia
    Title: Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K29-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K29-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF186
NP_080062.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025786.4 → NP_080062.5  E3 ubiquitin-protein ligase RNF186

    Status: VALIDATED

    Source sequence(s)
    AL805923
    Consensus CDS
    CCDS51338.1
    UniProtKB/Swiss-Prot
    Q78R58, Q9D241
    UniProtKB/TrEMBL
    A2ALL3
    Related
    ENSMUSP00000111780.4, ENSMUST00000116094.5
    Conserved Domains (2) summary
    COG5432
    Location:37 → 153
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cl17238
    Location:36 → 86
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138694430..138695676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D241.3 GenPept UniProtKB/Swiss-Prot:Q9D241

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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