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Fbxo25 F-box protein 25 [ Mus musculus (house mouse) ]

Gene ID: 66822, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxo25provided by MGI
Official Full Name
F-box protein 25provided by MGI
Primary source
MGI:MGI:1914072
See related
Ensembl:ENSMUSG00000038365 AllianceGenome:MGI:1914072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbx25; 9130015I06Rik
Summary
Predicted to enable actin binding activity. Involved in protein ubiquitination. Located in nucleus. Part of SCF ubiquitin ligase complex. Is expressed in intestine; nervous system; and sensory organ. Orthologous to human FBXO25 (F-box protein 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 42.5), colon adult (RPKM 41.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxo25 in Genome Data Viewer
Location:
8 A1.1; 8 6.42 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13957667..13992862)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13907736..13942875)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coordinator of PRMT5, differentiation stimulator Neighboring gene interferon induced transmembrane protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr8:13907572-13907873 Neighboring gene STARR-seq mESC enhancer starr_20776 Neighboring gene testis development related protein Neighboring gene STARR-seq mESC enhancer starr_20780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13992606-13992862 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13996330-13996563 Neighboring gene predicted gene 5907 Neighboring gene predicted gene, 53401

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors. Jang JW, et al. Biochem Biophys Res Commun, 2011 Jul 1. PMID 21596019
  2. FBXO25-associated nuclear domains: a novel subnuclear structure. Manfiolli AO, et al. Mol Biol Cell, 2008 May. PMID 18287534, Free PMC Article
  3. Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development. Jeong HS, et al. Biochim Biophys Acta, 2015 Jun. PMID 25725482
  4. Characterization of FBX25, encoding a novel brain-expressed F-box protein. Hagens O, et al. Biochim Biophys Acta, 2006 Jan. PMID 16278047
  5. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Xue W, et al. Proc Natl Acad Sci U S A, 2012 May 22. PMID 22566646, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 and Tbx5 ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 and Tbx5 transcriptional activity.
    Title: Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development.
  2. Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5, Isl1, and Hand1, indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development.
    Title: A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors.
  3. The cellular distribution of FBXO25 and its colocalization with some nuclear proteins is investigated by using immunochemical and biochemical approaches.
    Title: FBXO25-associated nuclear domains: a novel subnuclear structure.
  4. mFbx25 shows predominantly neuronal expression and in adult mouse brain, expression is confined to the hippocampus, the cerebral cortex and the Purkinje cell layer
    Title: Characterization of FBX25, encoding a novel brain-expressed F-box protein.
  5. FBXO25 is a novel F-box protein analogous to atrogin-1, which is not involved in muscle atrophy.
    Title: FBXO25, an F-box protein homologue of atrogin-1, is not induced in atrophying muscle.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box only protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347316.1 → NP_001334245.1  F-box only protein 25 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses and alternate in-frame splice site, compared to variant 3. The encoded isoform (1) is shorter than isoform 3.
    Source sequence(s)
    AC139186, AK134722, CJ147979
    Consensus CDS
    CCDS85507.1
    UniProtKB/TrEMBL
    A0A1B0GRC8, Q3UYF5
    Related
    ENSMUSP00000147467.2, ENSMUST00000209913.2

  2. NM_001359061.1 → NP_001345990.1  F-box only protein 25 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3)
    Source sequence(s)
    AC139186
    UniProtKB/TrEMBL
    Q3UYF5

  3. NM_025785.3 → NP_080061.1  F-box only protein 25 isoform 2

    See identical proteins and their annotated locations for NP_080061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 3. The encoded isoform (2) is shorter than isoform 3.
    Source sequence(s)
    AC139186
    Consensus CDS
    CCDS22118.1
    UniProtKB/Swiss-Prot
    Q9D2Y6, Q9D8H3
    UniProtKB/TrEMBL
    Q3UYF5
    Related
    ENSMUSP00000039544.4, ENSMUST00000043520.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13957667..13992862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243729.2 → XP_030099589.1  F-box only protein 25 isoform X1

    UniProtKB/TrEMBL
    Q3UYF5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2Y6.1 GenPept UniProtKB/Swiss-Prot:Q9D2Y6

Gene LinkOut

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