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Bin2 bridging integrator 2 [ Mus musculus (house mouse) ]

Gene ID: 668218, updated on 5-Mar-2024

Summary

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Official Symbol
Bin2provided by MGI
Official Full Name
bridging integrator 2provided by MGI
Primary source
MGI:MGI:3611448
See related
Ensembl:ENSMUSG00000098112 AllianceGenome:MGI:3611448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable phospholipid binding activity. Predicted to be involved in several processes, including phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Predicted to be active in plasma membrane and podosome. Predicted to colocalize with phagocytic cup. Is expressed in liver and thymus primordium. Orthologous to human BIN2 (bridging integrator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 26.2), thymus adult (RPKM 18.8) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F1; 15 56.37 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100538963..100567384, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100641082..100669503, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 2 Neighboring gene small cell adhesion glycoprotein Neighboring gene microRNA 6961 Neighboring gene STARR-positive B cell enhancer ABC_E311 Neighboring gene chymotrypsin-like elastase family, member 1 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation. Volz J, et al. J Clin Invest, 2020 Nov 2. PMID 32750041, Free PMC Article
  2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice.
    Title: Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice.
  2. BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation.
    Title: BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in podosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in podosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with phagocytic cup IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with phagocytic cup ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in podosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bridging integrator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270537.2 → NP_001257466.1  bridging integrator 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123724
    Consensus CDS
    CCDS59622.1
    UniProtKB/TrEMBL
    S4R1B8, S4R270
    Related
    ENSMUSP00000138523.2, ENSMUST00000183211.8
    Conserved Domains (1) summary
    cl12013
    Location:30 → 240
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_001368666.1 → NP_001355595.1  bridging integrator 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123724
    UniProtKB/TrEMBL
    S4R1B8
    Related
    ENSMUSP00000159169.2, ENSMUST00000238935.2
    Conserved Domains (1) summary
    cl12013
    Location:30 → 240
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100538963..100567384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521281.2 → XP_006521344.1  bridging integrator 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z6Q9.1 GenPept UniProtKB/Swiss-Prot:D3Z6Q9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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