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Ccdc85c coiled-coil domain containing 85C [ Mus musculus (house mouse) ]

Gene ID: 668158, updated on 21-Apr-2024

Summary

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Official Symbol
Ccdc85cprovided by MGI
Official Full Name
coiled-coil domain containing 85Cprovided by MGI
Primary source
MGI:MGI:3644008
See related
Ensembl:ENSMUSG00000084883 AllianceGenome:MGI:3644008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hhy; Gm265; Gm9010; EG668158
Summary
Involved in cerebral cortex development. Located in apical junction complex. Is expressed in brain; brain pia mater; brain subventricular zone; diencephalon; and telencephalon. Used to study hydrocephalus. Orthologous to human CCDC85C (coiled-coil domain containing 85C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 33.4), duodenum adult (RPKM 30.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 59.23 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108169858..108244111, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108203599..108277852, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109157062-109157245 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109164383-109164658 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109166259-109166489 Neighboring gene STARR-seq mESC enhancer starr_33230 Neighboring gene B cell leukemia/lymphoma 11B Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109202967-109203154 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109231387-109231540 Neighboring gene STARR-seq mESC enhancer starr_33235 Neighboring gene SET domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E743 Neighboring gene cyclin K Neighboring gene STARR-positive B cell enhancer mm9_chr12:109513689-109513989 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109514813-109514922 Neighboring gene STARR-positive B cell enhancer mm9_chr12:109572195-109572495 Neighboring gene hedgehog interacting protein-like 1 Neighboring gene cytochrome P450, family 46, subfamily a, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hemorrhagic hydrocephalus (hhy): a novel mutation on mouse chromosome 12. Kuwamura M, et al. Brain Res Dev Brain Res, 2004 Aug 18. PMID 15283996
  2. Ccdc85c encoding a protein at apical junctions of radial glia is disrupted in hemorrhagic hydrocephalus (hhy) mice. Mori N, et al. Am J Pathol, 2012 Jan. PMID 22056358
  3. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Chiang DY, et al. Circulation, 2018 Oct 9. PMID 29669786, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within radial glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical junction complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 85C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159910.2 → NP_001153382.1  coiled-coil domain-containing protein 85C

    See identical proteins and their annotated locations for NP_001153382.1

    Status: VALIDATED

    Source sequence(s)
    AC122407, AC152059
    Consensus CDS
    CCDS49166.1
    UniProtKB/Swiss-Prot
    E9Q6B2
    Related
    ENSMUSP00000152421.2, ENSMUST00000222310.2
    Conserved Domains (1) summary
    pfam10226
    Location:16 → 203
    DUF2216; Uncharacterized conserved proteins (DUF2216)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    108169858..108244111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516161.4 → XP_006516224.1  coiled-coil domain-containing protein 85C isoform X4

    Conserved Domains (1) summary
    pfam10226
    Location:16 → 203
    CCDC85; CCDC85 family

  2. XM_006516160.4 → XP_006516223.1  coiled-coil domain-containing protein 85C isoform X3

    Conserved Domains (1) summary
    pfam10226
    Location:16 → 203
    CCDC85; CCDC85 family

  3. XM_006516159.4 → XP_006516222.1  coiled-coil domain-containing protein 85C isoform X2

    Conserved Domains (1) summary
    pfam10226
    Location:16 → 203
    CCDC85; CCDC85 family

  4. XM_006516158.4 → XP_006516221.1  coiled-coil domain-containing protein 85C isoform X1

    UniProtKB/TrEMBL
    A0A217FL83
    Related
    ENSMUSP00000125757.3, ENSMUST00000136175.3
    Conserved Domains (1) summary
    pfam10226
    Location:16 → 203
    CCDC85; CCDC85 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q6B2.1 GenPept UniProtKB/Swiss-Prot:E9Q6B2

Gene LinkOut

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