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H2-T26 histocompatibility 2, T region locus 26 [ Mus musculus (house mouse) ]

Gene ID: 667977, updated on 8-Feb-2024

Summary

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Official Symbol
H2-T26provided by MGI
Official Full Name
histocompatibility 2, T region locus 26provided by MGI
Primary source
MGI:MGI:3704134
See related
Ensembl:ENSMUSG00000073402 AllianceGenome:MGI:3704134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2T5; H2-T5; Gm8909; H2-Tw5l; H2-gs17; EG667977
Summary
Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 70.8), small intestine adult (RPKM 58.6) and 13 other tissues See more
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Genomic context

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Location:
17 B1; 17 18.97 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36454704..36479490, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36143812..36168602, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility-2, T region locus 25 Neighboring gene histocompatibility 2, T region pseudogene Neighboring gene RIKEN cDNA 2410017I17 gene Neighboring gene predicted gene 10499 Neighboring gene akirin 1 pseudogene Neighboring gene akirin 1 pseudogene Neighboring gene histocompatibility 2, T region locus 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6. Ohtsuka M, et al. BMC Genomics, 2008 Apr 17. PMID 18416856, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC667977
Names
MHC class I like protein GS17
histocompatibility 2, T region locus 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081032.3 → NP_001074501.2  uncharacterized protein LOC667977 precursor

    See identical proteins and their annotated locations for NP_001074501.2

    Status: VALIDATED

    Source sequence(s)
    CT030728
    Consensus CDS
    CCDS37610.2
    UniProtKB/TrEMBL
    A7VMS6, E9Q0G4
    Related
    ENSMUSP00000036092.9, ENSMUST00000040467.15
    Conserved Domains (3) summary
    pfam00129
    Location:26 → 204
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cd00096
    Location:224 → 228
    Ig; Ig strand B [structural motif]
    cl11960
    Location:206 → 301
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36454704..36479490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246573.3 → XP_011244875.1  uncharacterized protein LOC667977 isoform X2

    Conserved Domains (1) summary
    pfam00129
    Location:55 → 232
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  2. XM_006524801.5 → XP_006524864.1  uncharacterized protein LOC667977 isoform X3

    UniProtKB/TrEMBL
    E9Q0G4
    Conserved Domains (3) summary
    cd07698
    Location:236 → 328
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:55 → 232
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:371 → 396
    MHC_I_C; MHC_I C-terminus

  3. XM_006524804.4 → XP_006524867.1  uncharacterized protein LOC667977 isoform X4

    UniProtKB/TrEMBL
    E9Q0G4
    Conserved Domains (3) summary
    cd07698
    Location:208 → 300
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:27 → 204
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:343 → 368
    MHC_I_C; MHC_I C-terminus

  4. XM_006524802.5 → XP_006524865.1  uncharacterized protein LOC667977 isoform X1

    UniProtKB/TrEMBL
    E9Q0G4, G3UXE9
    Related
    ENSMUSP00000133663.2, ENSMUST00000173353.8
    Conserved Domains (2) summary
    cd07698
    Location:236 → 328
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:55 → 232
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  5. XM_030249996.2 → XP_030105856.1  uncharacterized protein LOC667977 isoform X5

    Conserved Domains (2) summary
    cd07698
    Location:208 → 299
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:27 → 204
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
Nucleotide Protein Strain
Heading Accession and Version

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