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Grtp1 GH regulated TBC protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66790, updated on 11-Apr-2024

Summary

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Official Symbol
Grtp1provided by MGI
Official Full Name
GH regulated TBC protein 1provided by MGI
Primary source
MGI:MGI:1914040
See related
Ensembl:ENSMUSG00000038515 AllianceGenome:MGI:1914040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tbc1d6; 5430401C05Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and sensory organ. Orthologous to human GRTP1 (growth hormone regulated TBC protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 14.5), large intestine adult (RPKM 9.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A1.1; 8 5.73 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13226869..13250695, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13176869..13200766, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cullin 4A Neighboring gene STARR-seq mESC enhancer starr_20756 Neighboring gene microRNA 7065 Neighboring gene lysosomal-associated membrane protein 1 Neighboring gene RIKEN cDNA 2810030D12 gene Neighboring gene microRNA 1968 Neighboring gene STARR-seq mESC enhancer starr_20764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13213467-13213836 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13213972-13214173 Neighboring gene ADP-ribosylhydrolase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Grtp1, a novel gene regulated by growth hormone. Lu C, et al. Endocrinology, 2001 Oct. PMID 11564724
  2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
growth hormone-regulated TBC protein 1
Names
TBC1 domain family member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368858.1 → NP_001355787.1  growth hormone-regulated TBC protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK007905, AK017251, AK149322
    Consensus CDS
    CCDS90375.1
    UniProtKB/Swiss-Prot
    Q8BUR0, Q8VI03, Q9D3N8, Q9D3Q5, Q9D8L8
    UniProtKB/TrEMBL
    A0A1B0GSA2
    Related
    ENSMUSP00000130324.4, ENSMUST00000165605.4
    Conserved Domains (1) summary
    smart00164
    Location:71 → 301
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. NM_025768.2 → NP_080044.2  growth hormone-regulated TBC protein 1 isoform 1

    See identical proteins and their annotated locations for NP_080044.2

    Status: VALIDATED

    Source sequence(s)
    AK007905, AK149322
    Consensus CDS
    CCDS22107.1
    UniProtKB/TrEMBL
    A0A1B0GSA2
    Related
    ENSMUSP00000148042.2, ENSMUST00000210317.2
    Conserved Domains (1) summary
    smart00164
    Location:71 → 284
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13226869..13250695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508853.4 → XP_006508916.1  growth hormone-regulated TBC protein 1 isoform X3

    Conserved Domains (1) summary
    pfam00566
    Location:1 → 122
    RabGAP-TBC; Rab-GTPase-TBC domain

  2. XM_006508850.5 → XP_006508913.1  growth hormone-regulated TBC protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GSA2
    Conserved Domains (1) summary
    smart00164
    Location:71 → 284
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  3. XM_006508851.5 → XP_006508914.1  growth hormone-regulated TBC protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006508914.1

    UniProtKB/TrEMBL
    A0A1B0GSA2
    Related
    ENSMUSP00000147337.2, ENSMUST00000211128.2
    Conserved Domains (1) summary
    smart00164
    Location:71 → 284
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RNA

  1. XR_378665.4 RNA Sequence

  2. XR_003947326.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3N8.1 GenPept UniProtKB/Swiss-Prot:Q9D3N8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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