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Piezo2 piezo-type mechanosensitive ion channel component 2 [ Mus musculus (house mouse) ]

Gene ID: 667742, updated on 16-Apr-2024

Summary

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Official Symbol
Piezo2provided by MGI
Official Full Name
piezo-type mechanosensitive ion channel component 2provided by MGI
Primary source
MGI:MGI:1918781
See related
Ensembl:ENSMUSG00000041482 AllianceGenome:MGI:1918781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam38b; Fam38b2; 5930434P17; 9030411M15Rik; 9430028L06Rik
Summary
Enables mechanosensitive cation channel activity. Involved in detection of mechanical stimulus involved in sensory perception. Acts upstream of or within cation transport and regulation of membrane potential. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in dorsal root ganglion and lung. Human ortholog(s) of this gene implicated in distal arthrogryposis type 3 and distal arthrogryposis type 5. Orthologous to human PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 12.4), lung adult (RPKM 5.9) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E1; 18 35.95 cM
Exon count:
56
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63143284..63520787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (63010213..63387716, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene adenomatosis polyposis coli down-regulated 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:63137389-63137586 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein gamma Neighboring gene STARR-seq mESC enhancer starr_44784 Neighboring gene predicted gene, 36651 Neighboring gene STARR-seq mESC enhancer starr_44785 Neighboring gene STARR-seq mESC enhancer starr_44786 Neighboring gene STARR-seq mESC enhancer starr_44787 Neighboring gene STARR-seq mESC enhancer starr_44788 Neighboring gene predicted gene, 26972 Neighboring gene STARR-seq mESC enhancer starr_44790 Neighboring gene predicted gene, 23581

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Excessive mechanotransduction in sensory neurons causes joint contractures. Ma S, et al. Science, 2023 Jan 13. PMID 36634173, Free PMC Article
  2. Midpalatal Suture: Single-Cell RNA-Seq Reveals Intramembrane Ossification and Piezo2 Chondrogenic Mesenchymal Cell Involvement. Gao L, et al. Cells, 2022 Nov 12. PMID 36429014, Free PMC Article
  3. Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel PIEZO2. Hoffman BU, et al. Proc Natl Acad Sci U S A, 2022 May 24. PMID 35580186, Free PMC Article
  4. Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea. Fernández-Trillo J, et al. J Neurosci, 2020 Nov 18. PMID 33055278, Free PMC Article
  5. Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction. Michel N, et al. Cell Rep, 2020 Jul 21. PMID 32697985

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.
    Title: Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.
  2. Caldendrin Is a Repressor of PIEZO2 Channels and Touch Sensation in Mice.
    Title: Caldendrin Is a Repressor of PIEZO2 Channels and Touch Sensation in Mice.
  3. Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.
    Title: Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.
  4. PIEZO2 and perineal mechanosensation are essential for sexual function.
    Title: PIEZO2 and perineal mechanosensation are essential for sexual function.
  5. Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.
    Title: Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.
  6. PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
    Title: PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
  7. Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice.
    Title: Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice.
  8. Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.
    Title: Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.
  9. Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome.
    Title: Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome.
  10. Excessive mechanotransduction in sensory neurons causes joint contractures.
    Title: Excessive mechanotransduction in sensory neurons causes joint contractures.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (6) 

General gene information

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Markers

Homology

Clone Names

  • FLJ23403, MGC182702

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of mechanical stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
piezo-type mechanosensitive ion channel component 2
Names
family with sequence similarity 38, member B
family with sequence similarity 38, member B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039485.5 → NP_001034574.4  piezo-type mechanosensitive ion channel component 2

    Status: VALIDATED

    Source sequence(s)
    AC124391, AC132378, AC140554, AC162804
    Consensus CDS
    CCDS29296.2
    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    UniProtKB/TrEMBL
    E9QNW4
    Related
    ENSMUSP00000040019.6, ENSMUST00000047480.13
    Conserved Domains (2) summary
    pfam12166
    Location:2412 → 2821
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1383 → 1614
    PIEZO; Piezo

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    63143284..63520787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526169.4 → XP_006526232.1  piezo-type mechanosensitive ion channel component 2 isoform X4

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    Conserved Domains (2) summary
    pfam12166
    Location:2417 → 2826
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1355 → 1622
    PIEZO; Piezo

  2. XM_006526168.4 → XP_006526231.1  piezo-type mechanosensitive ion channel component 2 isoform X3

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    Conserved Domains (2) summary
    pfam12166
    Location:2418 → 2827
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1356 → 1623
    PIEZO; Piezo

  3. XM_006526173.4 → XP_006526236.1  piezo-type mechanosensitive ion channel component 2 isoform X7

    UniProtKB/TrEMBL
    A0A494B9V6, S4R2S0
    Related
    ENSMUSP00000138758.3, ENSMUST00000183217.9
    Conserved Domains (2) summary
    pfam12166
    Location:2341 → 2750
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1368 → 1602
    PIEZO; Piezo

  4. XM_006526167.4 → XP_006526230.1  piezo-type mechanosensitive ion channel component 2 isoform X2

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    Conserved Domains (2) summary
    pfam12166
    Location:2430 → 2839
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1368 → 1635
    PIEZO; Piezo

  5. XM_036161249.1 → XP_036017142.1  piezo-type mechanosensitive ion channel component 2 isoform X8

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    UniProtKB/TrEMBL
    A0A2H4UKA3
    Conserved Domains (2) summary
    pfam12166
    Location:2455 → 2864
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1393 → 1660
    PIEZO; Piezo

  6. XM_006526170.4 → XP_006526233.1  piezo-type mechanosensitive ion channel component 2 isoform X5

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    Conserved Domains (2) summary
    pfam12166
    Location:2398 → 2807
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1369 → 1603
    PIEZO; Piezo

  7. XM_006526172.4 → XP_006526235.1  piezo-type mechanosensitive ion channel component 2 isoform X6

    UniProtKB/TrEMBL
    A0A494B9V6
    Conserved Domains (2) summary
    pfam12166
    Location:2375 → 2784
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1369 → 1636
    PIEZO; Piezo

  8. XM_006526166.4 → XP_006526229.1  piezo-type mechanosensitive ion channel component 2 isoform X1

    UniProtKB/Swiss-Prot
    E2JF23, Q8BSM4, Q8CD54, Q9D341
    Conserved Domains (2) summary
    pfam12166
    Location:2431 → 2840
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1369 → 1636
    PIEZO; Piezo

RNA

  1. XR_386006.4 RNA Sequence

  2. XR_001782388.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172629.1: Suppressed sequence

    Description
    NM_172629.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CD54.2 GenPept UniProtKB/Swiss-Prot:Q8CD54

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