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Zfp600 zinc finger protein 600 [ Mus musculus (house mouse) ]

Gene ID: 667666, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp600provided by MGI
Official Full Name
zinc finger protein 600provided by MGI
Primary source
MGI:MGI:3705222
See related
Ensembl:ENSMUSG00000066007 AllianceGenome:MGI:3705222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm13164
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in epiblast; primitive endoderm; and trophectoderm. Orthologous to human ZNF267 (zinc finger protein 267) and ZNF600 (zinc finger protein 600). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
4 E1; 4 78.38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (146093397..146135326)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (146156827..146198756)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13035 Neighboring gene STARR-seq mESC enhancer starr_12043 Neighboring gene STARR-seq mESC enhancer starr_12044 Neighboring gene zinc finger protein 987 Neighboring gene vomeronasal 2, receptor, pseudogene 17 Neighboring gene predicted gene 13165 Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene 13167 Neighboring gene protein phosphatase 2, regulatory subunit B', alpha pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 600

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177545.2 → NP_001171016.1  zinc finger protein 600

    See identical proteins and their annotated locations for NP_001171016.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL606987, BC108352, CD541204, CD542866
    Consensus CDS
    CCDS51373.1
    UniProtKB/TrEMBL
    A2A7V0, E9PW48
    Related
    ENSMUSP00000090425.6, ENSMUST00000092750.12
    Conserved Domains (5) summary
    smart00349
    Location:28 → 70
    KRAB; krueppel associated box
    COG5048
    Location:333 → 730
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:28 → 67
    KRAB; KRAB box
    pfam13465
    Location:321 → 346
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001177546.2 → NP_001171017.1  zinc finger protein 600

    See identical proteins and their annotated locations for NP_001171017.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL606987
    Consensus CDS
    CCDS51373.1
    UniProtKB/TrEMBL
    A2A7V0, E9PW48
    Related
    ENSMUSP00000126879.3, ENSMUST00000168483.9
    Conserved Domains (5) summary
    smart00349
    Location:28 → 70
    KRAB; krueppel associated box
    COG5048
    Location:333 → 730
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:28 → 67
    KRAB; KRAB box
    pfam13465
    Location:321 → 346
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    146093397..146135326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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