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Cypt1 cysteine-rich perinuclear theca 1 [ Mus musculus (house mouse) ]

Gene ID: 66742, updated on 8-Feb-2024

Summary

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Official Symbol
Cypt1provided by MGI
Official Full Name
cysteine-rich perinuclear theca 1provided by MGI
Primary source
MGI:MGI:3616441
See related
Ensembl:ENSMUSG00000023257 AllianceGenome:MGI:3616441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cypt5; Cypt6; Ckt1r3; TISP55; 4931420D14Rik
Summary
Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 74.3) See more
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Genomic context

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Location:
X A1.2; X 11.68 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (16389108..16389930)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (16522869..16523691)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46816 Neighboring gene predicted gene, 23516 Neighboring gene cysteine-rich perinuclear theca 11, pseudogene Neighboring gene STARR-seq mESC enhancer starr_46817 Neighboring gene STARR-seq mESC enhancer starr_46818 Neighboring gene casein kinase 2, alpha 1 polypeptide, pseudogene 2 Neighboring gene Kruppel-like factor 17 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a novel postacrosomal perinuclear theca-specific protein, CYPT1. Kitamura K, et al. Biol Reprod, 2004 Dec. PMID 15286030
  2. Identification and expression profiling of 10 novel spermatid expressed CYPT genes. Hansen MA, et al. Mol Reprod Dev, 2006 May. PMID 16477651
  3. A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family. Hansen MA, et al. Mol Reprod Dev, 2008 Feb. PMID 17342728
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human VCX/Y, SPANX, and CSAG2 gene families together with the murine SPANX gene and the CYPT family may share a common ancestor.
    Title: A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.
  2. CYPT1 and the proteins of the paralogous genes constitute a novel, basic cysteine-rich sperm protein family that may contribute to the function of the postacrosomal PT during nuclear shaping.
    Title: Characterization of a novel postacrosomal perinuclear theca-specific protein, CYPT1.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC74194

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cysteine-rich perinuclear theca protein 1
Names
basic protein CKT1R3
cysteine-rich perinuclear theca 5
cysteine-rich perinuclear theca 6
cysteine-rich postacrosomal PT protein
cysteine-rich postacrosomal perinuclear theca protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310461.1 → NP_001297390.1  cysteine-rich perinuclear theca protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001297390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK006892, AL805907
    Consensus CDS
    CCDS81101.1
    UniProtKB/Swiss-Prot
    B1AX51, Q3MSD0, Q3MSD1, Q6P8T4, Q8CH20, Q9D4K2, Q9D9I2
    UniProtKB/TrEMBL
    Q3MSC8
    Related
    ENSMUSP00000111082.2, ENSMUST00000115422.2

  2. NM_025738.3 → NP_080014.2  cysteine-rich perinuclear theca protein 1 isoform 1

    See identical proteins and their annotated locations for NP_080014.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AK016467, AL805907
    Consensus CDS
    CCDS40880.1
    UniProtKB/TrEMBL
    Q3MSC8
    Related
    ENSMUSP00000024026.3, ENSMUST00000024026.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    16389108..16389930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CH20.1 GenPept UniProtKB/Swiss-Prot:Q8CH20

Gene LinkOut

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