U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Map1lc3a microtubule-associated protein 1 light chain 3 alpha [ Mus musculus (house mouse) ]

Gene ID: 66734, updated on 5-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Map1lc3aprovided by MGI
Official Full Name
microtubule-associated protein 1 light chain 3 alphaprovided by MGI
Primary source
MGI:MGI:1915661
See related
Ensembl:ENSMUSG00000027602 AllianceGenome:MGI:1915661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LC3; LC3a; 1010001H21Rik; 4922501H04Rik
Summary
Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in autophagy of mitochondrion; cellular response to nitrogen starvation; and macroautophagy. Located in autophagosome membrane. Is expressed in several structures, including central nervous system; heart; limb; peripheral nervous system ganglion; and sensory organ. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 1282.1), testis adult (RPKM 360.7) and 14 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2 H1; 2 77.18 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155118284..155119993)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155276364..155278073)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52565 Neighboring gene dynein light chain roadblock-type 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene STARR-positive B cell enhancer ABC_E6004 Neighboring gene microRNA 695 Neighboring gene STARR-positive B cell enhancer ABC_E11173 Neighboring gene STARR-positive B cell enhancer ABC_E4511 Neighboring gene transformation related protein 53 inducible nuclear protein 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging. Inomata M, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33376222, Free PMC Article
  2. Hepatic LC3 II/I ratio is not modulated in exercised mice. Marafon BB, et al. Physiol Res, 2020 Dec 22. PMID 33129244, Free PMC Article
  3. Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy. Park S, et al. Autophagy, 2016 Jul 2. PMID 27172324, Free PMC Article
  4. LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice. Hung SY, et al. Neuropharmacology, 2015 Jun. PMID 25686800
  5. Host and bacterial factors that regulate LC3 recruitment to Listeria monocytogenes during the early stages of macrophage infection. Lam GY, et al. Autophagy, 2013 Jul. PMID 23584039, Free PMC Article

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DAP1 regulates osteoblast autophagy via the ATG16L1-LC3 axis in Graves' disease-induced osteoporosis.
    Title: DAP1 regulates osteoblast autophagy via the ATG16L1-LC3 axis in Graves' disease-induced osteoporosis.
  2. Tumor cell-released LC3-positive EVs promote lung metastasis of breast cancer through enhancing premetastatic niche formation.
    Title: Tumor cell-released LC3-positive EVs promote lung metastasis of breast cancer through enhancing premetastatic niche formation.
  3. Loss of FYCO1 leads to cataract formation.
    Title: Loss of FYCO1 leads to cataract formation.
  4. Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke.
    Title: Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke.
  5. Hepatic LC3 II/I ratio is not modulated in exercised mice.
    Title: Hepatic LC3 II/I ratio is not modulated in exercised mice.
  6. Trimetazidine alleviates hypoxia/reoxygenation-induced apoptosis in neonatal mice cardiomyocytes via up-regulating HMGB1 expression to promote autophagy.
    Title: Trimetazidine alleviates hypoxia/reoxygenation-induced apoptosis in neonatal mice cardiomyocytes via up-regulating HMGB1 expression to promote autophagy.
  7. Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages.
    Title: Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages.
  8. Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3.
    Title: Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3.
  9. Japanese encephalitis virus capsid protein interacts with non-lipidated MAP1LC3 on replication membranes and lipid droplets.
    Title: Japanese encephalitis virus capsid protein interacts with non-lipidated MAP1LC3 on replication membranes and lipid droplets.
  10. Scanning Electron-Assisted Dielectric Microscopy Reveals Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian Cells.
    Title: Scanning Electron-Assisted Dielectric Microscopy Reveals Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian Cells.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in autolysosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
microtubule-associated proteins 1A/1B light chain 3A
Names
MAP1 light chain 3-like protein 1
MAP1A/MAP1B LC3 A
MAP1A/MAP1B light chain 3 A
autophagy-related protein LC3 A
autophagy-related ubiquitin-like modifier LC3 A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025735.3 → NP_080011.1  microtubule-associated proteins 1A/1B light chain 3A

    See identical proteins and their annotated locations for NP_080011.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is the protein-coding transcript.
    Source sequence(s)
    AK003122, BE993199, CA322683
    Consensus CDS
    CCDS16945.1
    UniProtKB/Swiss-Prot
    A2AVS1, Q91VR7, Q9DC74
    Related
    ENSMUSP00000029128.4, ENSMUST00000029128.4
    Conserved Domains (1) summary
    cd17234
    Location:4 → 120
    Ubl_ATG8_MAP1LC3A; ubiquitin-like (Ubl) domain found in microtubule associate protein 1 light chain 3A (MAP1LC3A)

RNA

  1. NR_046364.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK003122, BE993199, CA322683
    Related
    ENSMUST00000145086.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155118284..155119993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VR7.1 GenPept UniProtKB/Swiss-Prot:Q91VR7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous