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Henmt1 HEN1 methyltransferase homolog 1 (Arabidopsis) [ Mus musculus (house mouse) ]

Gene ID: 66715, updated on 11-Apr-2024

Summary

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Official Symbol
Henmt1provided by MGI
Official Full Name
HEN1 methyltransferase homolog 1 (Arabidopsis)provided by MGI
Primary source
MGI:MGI:1913965
See related
Ensembl:ENSMUSG00000045662 AllianceGenome:MGI:1913965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hen1; mHEN1; 4921515J06Rik
Summary
Enables O-methyltransferase activity and RNA methyltransferase activity. Involved in RNA methylation and piRNA metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human HENMT1 (HEN methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 4.7) and CNS E18 (RPKM 0.3) See more
Orthologs
human all
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Genomic context

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See Henmt1 in Genome Data Viewer
Location:
3 F3; 3 47.99 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108846770..108887201)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108939454..108979885)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E3460 Neighboring gene STARR-positive B cell enhancer ABC_E4576 Neighboring gene PRP38 pre-mRNA processing factor 38 (yeast) domain containing B Neighboring gene EEIG family member 2 Neighboring gene predicted gene 43221 Neighboring gene STARR-positive B cell enhancer mm9_chr3:108830639-108830939 Neighboring gene STARR-positive B cell enhancer mm9_chr3:108865935-108866236 Neighboring gene predicted gene, 36778

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HENMT1 is involved in the maintenance of normal female fertility in the mouse. Hutt KJ, et al. Mol Hum Reprod, 2021 Nov 2. PMID 34590701
  2. Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability. Gainetdinov I, et al. Mol Cell, 2021 Dec 2. PMID 34626567, Free PMC Article
  3. Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain. Peng L, et al. J Biol Chem, 2018 Jun 29. PMID 29703750, Free PMC Article
  4. HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. Lim SL, et al. PLoS Genet, 2015 Oct. PMID 26496356, Free PMC Article
  5. 2'-O-methyl modification in mouse piRNAs and its methylase. Kirino Y, et al. Nucleic Acids Symp Ser (Oxf), 2007. PMID 18029764

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HENMT1 is involved in the maintenance of normal female fertility in the mouse.
    Title: HENMT1 is involved in the maintenance of normal female fertility in the mouse.
  2. methylation substrates in mouse spermatogonial stem cells and the substrate-recognition mechanism of mammalian Hen1
    Title: Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain.
  3. DNA damage and a catastrophic deregulation of the haploid germ cell gene expression. Collectively these results define a critical role for HENMT1 and piRNAs in the maintenance of TE repression in adult germ cells and setting the spermatogenic program.
    Title: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC117573

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-methyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables small RNA 2'-O-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA methylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in siRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
small RNA 2'-O-methyltransferase
NP_001072114.1
NP_079999.2
XP_006501961.1
XP_036019121.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001078646.1 → NP_001072114.1  small RNA 2'-O-methyltransferase

    See identical proteins and their annotated locations for NP_001072114.1

    Status: VALIDATED

    Source sequence(s)
    AK038994, BC099408
    Consensus CDS
    CCDS38602.1
    UniProtKB/Swiss-Prot
    A2VCS5, Q8C3K8, Q8CAE2
    Related
    ENSMUSP00000102196.3, ENSMUST00000106586.7
    Conserved Domains (2) summary
    cl02755
    Location:341 → 380
    LAM; LA motif RNA-binding domain
    cl17173
    Location:34 → 168
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_025723.2 → NP_079999.2  small RNA 2'-O-methyltransferase

    See identical proteins and their annotated locations for NP_079999.2

    Status: VALIDATED

    Source sequence(s)
    BC099408, DV650789
    Consensus CDS
    CCDS38602.1
    UniProtKB/Swiss-Prot
    A2VCS5, Q8C3K8, Q8CAE2
    Related
    ENSMUSP00000054829.5, ENSMUST00000059946.11
    Conserved Domains (2) summary
    cl02755
    Location:341 → 380
    LAM; LA motif RNA-binding domain
    cl17173
    Location:34 → 168
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108846770..108887201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501898.3 → XP_006501961.1  small RNA 2'-O-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q8CAE2
    Conserved Domains (2) summary
    COG2227
    Location:83 → 134
    UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]
    pfam13649
    Location:9 → 103
    Methyltransf_25; Methyltransferase domain

  2. XM_036163228.1 → XP_036019121.1  small RNA 2'-O-methyltransferase isoform X1

    Related
    ENSMUSP00000143574.2, ENSMUST00000196533.2
    Conserved Domains (2) summary
    COG2227
    Location:83 → 134
    UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]
    pfam13649
    Location:9 → 103
    Methyltransf_25; Methyltransferase domain

RNA

  1. XR_003954369.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CAE2.1 GenPept UniProtKB/Swiss-Prot:Q8CAE2

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