Zbed6 zinc finger, BED type containing 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbed6provided by MGI
Official Full Name: zinc finger, BED type containing 6provided by MGI
Primary source: MGI:MGI:3828086
See related: Ensembl:ENSMUSG00000094410 AllianceGenome:MGI:3828086
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MGR; Gm8466; Gm38394
Summary: Enables transcription cis-regulatory region binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of insulin secretion involved in cellular response to glucose stimulus; and type B pancreatic cell differentiation. Acts upstream of or within blastocyst hatching. Located in cytoplasm and nucleolus. Is expressed in early conceptus; nervous system; neural retina; and secondary oocyte. Orthologous to human ZBED6 (zinc finger BED-type containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 1; 1 E4

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (133547606..133589112, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (133655879..133660885, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation.
Title: ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation.
Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs.
Title: Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs.
The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells.
Title: The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells.
the effect of ZBED6 on growth of muscle and internal organs is mediated through the binding site in the Igf2 gene
Title: The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals.
Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro.
Title: Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro.
ZBED6 inhibits IGF2 activity.
Title: Transcription factor ZBED6 mediates IGF2 gene expression by regulating promoter activity and DNA methylation in myoblasts.
We propose that ZBED6 preferentially binds to active promoters and modulates transcriptional activity without recruiting repressive histone modifications.
Title: ZBED6 modulates the transcription of myogenic genes in mouse myoblast cells.
Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells.
Title: Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells.
Silencing of Zbed6 in mouse C2C12 myoblasts affected Igf2 expression, cell proliferation, wound healing, and myotube formation.
Title: ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.
muscle growth regulator (MGR) is a repressor of Igf2
Title: A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger BED domain-containing protein 6

Names: muscle growth regulator; zinc finger, BED domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166552.2 → NP_001160024.1 zinc finger BED domain-containing protein 6

See identical proteins and their annotated locations for NP_001160024.1

Status: VALIDATED

Source sequence(s)

AC124338

Consensus CDS

CCDS56643.1

UniProtKB/Swiss-Prot

D2EAC2, D2EAC3, Q3UMD3, Q8C1U4, Q8CBM9

UniProtKB/TrEMBL

G0LE24

Conserved Domains (2) summary

smart00614
Location:135 → 182

ZnF_BED; BED zinc finger

pfam05699
Location:870 → 950

Dimer_Tnp_hAT; hAT family C-terminal dimerization region
NM_001395904.1 → NP_001382833.1 zinc finger BED domain-containing protein 6

Status: VALIDATED

Source sequence(s)

AC124338

UniProtKB/Swiss-Prot

D2EAC2, D2EAC3, Q3UMD3, Q8C1U4, Q8CBM9

UniProtKB/TrEMBL

G0LE24

Related

ENSMUSP00000136026.2, ENSMUST00000179598.4

Conserved Domains (2) summary

smart00614
Location:135 → 182

ZnF_BED; BED zinc finger

pfam05699
Location:870 → 950

Dimer_Tnp_hAT; hAT family C-terminal dimerization region