Ndufaf3 NADH:ubiquinone oxidoreductase complex assembly factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufaf3provided by MGI
Official Full Name: NADH:ubiquinone oxidoreductase complex assembly factor 3provided by MGI
Primary source: MGI:MGI:1913956
See related: Ensembl:ENSMUSG00000070283 AllianceGenome:MGI:1913956
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4733401H18Rik
Summary: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 18. Orthologous to human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 180.2), adrenal adult (RPKM 40.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.5 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108442786..108444635, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108565587..108567436, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

4733401H18Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in mitochondrial respiratory chain complex I assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

Names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3; nuclear protein E3-3; protein 2P1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023247.2 → NP_075736.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

See identical proteins and their annotated locations for NP_075736.1

Status: VALIDATED

Source sequence(s)

AF235017, AI837285, CT010508

Consensus CDS

CCDS23531.1

UniProtKB/Swiss-Prot

Q8K1A3, Q9JKL4

Related

ENSMUSP00000073832.5, ENSMUST00000074208.6

Conserved Domains (1) summary

cd05125
Location:59 → 172

Mth938_2P1-like; Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the ...