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Ms4a4a membrane-spanning 4-domains, subfamily A, member 4A [ Mus musculus (house mouse) ]

Gene ID: 666907, updated on 5-Mar-2024

Summary

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Official Symbol
Ms4a4aprovided by MGI
Official Full Name
membrane-spanning 4-domains, subfamily A, member 4Aprovided by MGI
Primary source
MGI:MGI:3643932
See related
Ensembl:ENSMUSG00000101389 AllianceGenome:MGI:3643932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG666907
Summary
Predicted to be located in Golgi apparatus; endoplasmic reticulum; and plasma membrane raft. Orthologous to human MS4A4A (membrane spanning 4-domains A4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 1.3), bladder adult (RPKM 1.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 8.44 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11352827..11370682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11375488..11392915)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene membrane-spanning 4-domains, subfamily A, member 14 Neighboring gene membrane-spanning 4-domains, subfamily A, member 7 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene membrane-spanning 4-domains, subfamily A, member 4C Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice. Sui Y, et al. Eur J Immunol, 2020 Oct. PMID 32589266
  2. The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis. Mattiola I, et al. Nat Immunol, 2019 Aug. PMID 31263276, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice.
    Title: MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
membrane-spanning 4-domains subfamily A member 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310331.1 → NP_001297260.1  membrane-spanning 4-domains subfamily A member 4A

    Status: VALIDATED

    Source sequence(s)
    AC125406
    Consensus CDS
    CCDS79692.1
    UniProtKB/TrEMBL
    A0A087WRT7
    Related
    ENSMUSP00000140768.2, ENSMUST00000188995.2
    Conserved Domains (1) summary
    pfam04103
    Location:46 → 188
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    11352827..11370682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161653.1 → XP_036017546.1  membrane-spanning 4-domains subfamily A member 4A isoform X1

    Conserved Domains (1) summary
    pfam04103
    Location:46 → 91
    CD20; CD20-like family
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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