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Tmem41a transmembrane protein 41a [ Mus musculus (house mouse) ]

Gene ID: 66664, updated on 21-Apr-2024

Summary

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Official Symbol
Tmem41aprovided by MGI
Official Full Name
transmembrane protein 41aprovided by MGI
Primary source
MGI:MGI:1913914
See related
Ensembl:ENSMUSG00000022856 AllianceGenome:MGI:1913914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900010K02Rik; 5730578N08Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human TMEM41A (transmembrane protein 41A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 37.9), large intestine adult (RPKM 29.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B1; 16 12.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (21753077..21766302, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (21934327..21947552, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 13 Neighboring gene predicted gene, 26744 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40374 Neighboring gene lipase, member H Neighboring gene STARR-seq mESC enhancer starr_40375 Neighboring gene STARR-seq mESC enhancer starr_40377 Neighboring gene STARR-seq mESC enhancer starr_40378 Neighboring gene STARR-positive B cell enhancer ABC_E393 Neighboring gene STARR-seq mESC enhancer starr_40381 Neighboring gene SUMO/sentrin specific peptidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of transmembrane protein 41A is associated with metastasis via the modulation of E‑cadherin in radically resected gastric cancer. Lin B, et al. Mol Med Rep, 2018 Sep. PMID 30015937
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 41A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025693.4 → NP_079969.1  transmembrane protein 41A precursor

    See identical proteins and their annotated locations for NP_079969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes a functional protein.
    Source sequence(s)
    AK007685, AK013518, BB873279
    Consensus CDS
    CCDS28064.1
    UniProtKB/Swiss-Prot
    Q9D8U2
    Related
    ENSMUSP00000023562.8, ENSMUST00000023562.9
    Conserved Domains (1) summary
    pfam09335
    Location:85 → 205
    SNARE_assoc; SNARE associated Golgi protein

RNA

  1. NR_037773.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK013518, BB853849, BB873279
    Related
    ENSMUST00000232635.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    21753077..21766302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8U2.1 GenPept UniProtKB/Swiss-Prot:Q9D8U2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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