Acp6 acid phosphatase 6, lysophosphatidic [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acp6provided by MGI
Official Full Name: acid phosphatase 6, lysophosphatidicprovided by MGI
Primary source: MGI:MGI:1931010
See related: Ensembl:ENSMUSG00000028093 AllianceGenome:MGI:1931010
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ACPL1; mPACPL1; 5730559A09Rik
Summary: Predicted to enable lysophosphatidic acid phosphatase activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human ACP6 (acid phosphatase 6, lysophosphatidic). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 20.3), large intestine adult (RPKM 18.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 42.04 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (97066070..97083892)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (97158752..97176576)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

acid phosphatase-like protein 1 from human intestinal tissue could be associated with interstitial cells of Cajal function ACPL1
Title: Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_26738-26739:1034169915:1 (e-PCR)
- UniSTS:269064

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

AU022842 (e-PCR)
- UniSTS:207539

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lysobisphosphatidic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysobisphosphatidic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophosphatidic acid phosphatase type 6

Names: PACPL1; acid phosphatase like 1; acid phosphatase-like protein 1

NP_062774.2

EC 3.1.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019800.4 → NP_062774.2 lysophosphatidic acid phosphatase type 6 precursor

See identical proteins and their annotated locations for NP_062774.2

Status: VALIDATED

Source sequence(s)

AC140071, AK165356

Consensus CDS

CCDS17653.1

UniProtKB/Swiss-Prot

Q3TNE2, Q8BN33, Q8BP40, Q9JMG5, Q9QXG5

Related

ENSMUSP00000088263.5, ENSMUST00000090759.5

Conserved Domains (1) summary

cd07061
Location:42 → 371

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction